Mitochondrial adventures at the organelle society

Cátia V. Diogo, King Faisal Yambire, Lorena Fernández Mosquera, Tiago Branco F., Nuno Raimundo

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Mitochondria are constantly communicating with the rest of the cell. Defects in mitochondria underlie severe pathologies, whose mechanisms remain poorly understood. It is becoming increasingly evident that mitochondrial malfunction resonates in other organelles, perturbing their function and their biogenesis. In this manuscript, we review the current knowledge on the cross-talk between mitochondria and other organelles, particularly lysosomes, peroxisomes and the endoplasmic reticulum. Several organelle interactions are mediated by transcriptional programs, and other signaling mechanisms are likely mediating organelle dysfunction downstream of mitochondrial impairments. Many of these organelle crosstalk pathways are likely to have a role in pathological processes.

Original languageEnglish (US)
Pages (from-to)87-93
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume500
Issue number1
DOIs
StatePublished - May 27 2018

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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