Mitochondrial Ca2+ signaling

Trayambak Pathak, Mohamed Trebak

Research output: Contribution to journalReview article

13 Citations (Scopus)

Abstract

Mitochondrial Ca2+ regulation is crucial for bioenergetics and cellular signaling. The mechanisms controlling mitochondrial calcium homeostasis have been recently unraveled with the discovery of mitochondrial inner membrane proteins that regulate mitochondrial Ca2+ uptake and extrusion. Mitochondrial Ca2+ uptake depends on a large complex of proteins centered around the Ca2+ channel protein, mitochondrial Ca2+ uniporter (MCU) in close interactions with several regulatory subunits (MCUb, EMRE, MICU1, MICU2). Mitochondrial Ca2+ extrusion is mainly mediated by the mitochondrial Na+/Ca2+/Li+ exchanger (NCLX). Here, we review the major players of mitochondrial Ca2+ homeostasis and their physiological functions.

Original languageEnglish (US)
Pages (from-to)112-123
Number of pages12
JournalPharmacology and Therapeutics
Volume192
DOIs
StatePublished - Dec 2018

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Homeostasis
Mitochondrial Proteins
Energy Metabolism
Membrane Proteins
Calcium
Proteins

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)

Cite this

Pathak, Trayambak ; Trebak, Mohamed. / Mitochondrial Ca2+ signaling. In: Pharmacology and Therapeutics. 2018 ; Vol. 192. pp. 112-123.
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Mitochondrial Ca2+ signaling. / Pathak, Trayambak; Trebak, Mohamed.

In: Pharmacology and Therapeutics, Vol. 192, 12.2018, p. 112-123.

Research output: Contribution to journalReview article

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