Mitochondrial uncoupling protein 2 in the central nervous system: Neuromodulator and neuroprotector

Tamas L. Horvath, Sabrina Diano, Colin Barnstable

Research output: Contribution to journalReview article

77 Citations (Scopus)

Abstract

Uncoupling proteins (UCPs) are localized in the inner membrane of the mitochondria in diverse tissues and decrease mitochondrial membrane potential. The first of these proteins, UCP1, was discovered in brown adipose tissue, where it has a well-described role in thermogenesis. The functional significance of other UCPs, including UCP2, is less well understood. Here we summarize the recent advancements on the role of UCP2 in the brain and portray this uncoupler as an important player in normal neuronal function as well as a key cell death-suppressing device. These previously unknown functions of UCPs offer new avenues not only for the better understanding of these proteins but also for the furthering of our knowledge on the central nervous system in healthy and disease states.

Original languageEnglish (US)
Pages (from-to)1917-1921
Number of pages5
JournalBiochemical Pharmacology
Volume65
Issue number12
DOIs
StatePublished - Jun 15 2003

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Neurology
Neurotransmitter Agents
Central Nervous System
Proteins
Brown Adipose Tissue
Thermogenesis
Mitochondrial Membrane Potential
Tissue
Mitochondria
Membranes
Cell Death
Cell death
Equipment and Supplies
Brain
Mitochondrial Uncoupling Proteins
Uncoupling Protein 2

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Pharmacology

Cite this

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Mitochondrial uncoupling protein 2 in the central nervous system : Neuromodulator and neuroprotector. / Horvath, Tamas L.; Diano, Sabrina; Barnstable, Colin.

In: Biochemical Pharmacology, Vol. 65, No. 12, 15.06.2003, p. 1917-1921.

Research output: Contribution to journalReview article

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