Mitotic kinesins: A reason to delve into kinesin-12

Research output: Contribution to journalShort survey

6 Citations (Scopus)

Abstract

The failure of kinesin-targeting cancer drugs is thought to result from functional redundancy of mitotic kinesins. A new study provides mechanistic insights into kinesin-12 that help to explain its targeting to kinetochore fibers and its ability to compensate for inhibition of kinesin-5.

Original languageEnglish (US)
Pages (from-to)R968-R970
JournalCurrent Biology
Volume24
Issue number19
DOIs
StatePublished - Oct 6 2014

Fingerprint

Kinesin
kinesin
Kinetochores
kinetochores
Drug Delivery Systems
Redundancy
drugs
neoplasms
Fibers
Pharmaceutical Preparations
Neoplasms

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

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title = "Mitotic kinesins: A reason to delve into kinesin-12",
abstract = "The failure of kinesin-targeting cancer drugs is thought to result from functional redundancy of mitotic kinesins. A new study provides mechanistic insights into kinesin-12 that help to explain its targeting to kinetochore fibers and its ability to compensate for inhibition of kinesin-5.",
author = "Hancock, {William O.}",
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}

Mitotic kinesins : A reason to delve into kinesin-12. / Hancock, William O.

In: Current Biology, Vol. 24, No. 19, 06.10.2014, p. R968-R970.

Research output: Contribution to journalShort survey

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