Mitsunobu reactions of n-alkyl and n-acyl sulfonamides-an efficient route to protected amines

James R. Henry, Lawrence R. Marcin, Matthias C. McIntosh, Paul M. Scola, G. Davis Harris, Steven M. Weinreb

Research output: Contribution to journalArticle

218 Scopus citations

Abstract

N-Methyl p-toluenesulfonamide and N-BOC p-toluenesulfonamide can be directly coupled with primary and secondary alcohols under Mitsunobu conditions to afford various sulfonamide-protected amines.

Original languageEnglish (US)
Pages (from-to)5709-5712
Number of pages4
JournalTetrahedron Letters
Volume30
Issue number42
DOIs
StatePublished - 1989

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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    Henry, J. R., Marcin, L. R., McIntosh, M. C., Scola, P. M., Davis Harris, G., & Weinreb, S. M. (1989). Mitsunobu reactions of n-alkyl and n-acyl sulfonamides-an efficient route to protected amines. Tetrahedron Letters, 30(42), 5709-5712. https://doi.org/10.1016/S0040-4039(00)76177-6