Mob as tumor suppressor is activated at the cell membrane to control tissue growth and organ size in Drosophila

Li Lun Ho, Xiaomu Wei, Takeshi Shimizu, Zhi Chun Lai

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

Growth inhibition mediated by Hippo (Hpo) signaling is essential for tissue growth and organ size control in Drosophila. However, the cellular mechanism by which the core components like Mob as tumor suppressor (Mats) and Warts (Wts) protein kinase are activated is poorly understood. In this work, we found that the endogenous Mats is located at the plasma membrane in developing tissues. Membrane targeting constitutively activates Mats to promote apoptosis and reduce cell proliferation, which leads to reduced tissue growth and organ size. Moreover, the ability of membrane-targeted Mats to inhibit tissue growth required the wts gene activity and Wts kinase activity was increased by the activated Mats in developing tissues. Consistent with the idea that Mats is a key component of the Hpo pathway, Mats is required and sufficient to regulate Yki nuclear localization. These results support a model in which the plasma membrane is an important site of action for Mats tumor suppressor to control tissue growth and organ size.

Original languageEnglish (US)
Pages (from-to)274-283
Number of pages10
JournalDevelopmental biology
Volume337
Issue number2
DOIs
StatePublished - Jan 15 2010

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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