Model-based assessment and neural correlates of spatial memory deficits in mild cognitive impairment

Alexander S. Weigard, K. Sathian, Benjamin M. Hampstead

Research output: Contribution to journalArticle

Abstract

Mild cognitive impairment (MCI) is characterized by subjective and objective memory impairments within the context of generally intact everyday functioning. Such memory deficits are typically thought to arise from medial temporal lobe dysfunction; however, differences in memory task performance can arise from a variety of altered processes (e.g., strategy adjustments) rather than, or in addition to, “pure” memory deficits. To address this problem, we applied the linear ballistic accumulator (LBA: Brown and Heathcote, 2008) model to data from individuals with MCI (n = 18) and healthy older adults (HOA; n = 16) who performed an object-location association memory retrieval task during functional magnetic resonance imaging (fMRI). The primary goals were to 1) assess between-group differences in model parameters indexing processes of interest (memory sensitivity, accumulation speed, caution and time spent on peripheral perceptual and motor processes) and 2) determine whether differences in model-based metrics were consistent with fMRI data. The LBA provided evidence that, relative to the HOA group, those with MCI displayed lower sensitivity (i.e., difficulty discriminating targets from lures), suggestive of memory impairment, and displayed higher evidence accumulation speed and greater caution, suggestive of increased arousal and strategic changes in this group, although these changes had little impact on MCI-related accuracy differences. Consistent with these findings, fMRI revealed reduced activation in brain regions previously linked to evidence accumulation and to the implementation of caution reductions in the MCI group. Findings suggest that multiple cognitive mechanisms differ during memory retrieval in MCI, and that these mechanisms may explain neuroimaging alterations outside of the medial temporal lobes.

Original languageEnglish (US)
Article number107251
JournalNeuropsychologia
Volume136
DOIs
StatePublished - Jan 2020

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Memory Disorders
Magnetic Resonance Imaging
Temporal Lobe
Social Adjustment
Task Performance and Analysis
Arousal
Neuroimaging
Spatial Memory
Cognitive Dysfunction
Brain

All Science Journal Classification (ASJC) codes

  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

Cite this

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Model-based assessment and neural correlates of spatial memory deficits in mild cognitive impairment. / Weigard, Alexander S.; Sathian, K.; Hampstead, Benjamin M.

In: Neuropsychologia, Vol. 136, 107251, 01.2020.

Research output: Contribution to journalArticle

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