Model-based multifactor dimensionality reduction for detecting epistasis in case-control data in the presence of noise

Tom Cattaert, M. Luz Calle, Scott M. Dudek, Jestinah M. Mahachie John, François Van Lishout, Victor Urrea, Marylyn D. Ritchie, Kristel Van Steen

Research output: Contribution to journalArticlepeer-review

58 Scopus citations

Abstract

Analyzing the combined effects of genes and/or environmental factors on the development of complex diseases is a great challenge from both the statistical and computational perspective, even using a relatively small number of genetic and nongenetic exposures. Several data-mining methods have been proposed for interaction analysis, among them, the Multifactor Dimensionality Reduction Method (MDR) has proven its utility in a variety of theoretical and practical settings. Model-Based Multifactor Dimensionality Reduction (MB-MDR), a relatively new MDR-based technique that is able to unify the best of both nonparametric and parametric worlds, was developed to address some of the remaining concerns that go along with an MDR analysis. These include the restriction to univariate, dichotomous traits, the absence of flexible ways to adjust for lower order effects and important confounders, and the difficulty in highlighting epistatic effects when too many multilocus genotype cells are pooled into two new genotype groups. We investigate the empirical power of MB-MDR to detect gene-gene interactions in the absence of any noise and in the presence of genotyping error, missing data, phenocopy, and genetic heterogeneity. Power is generally higher for MB-MDR than for MDR, in particular in the presence of genetic heterogeneity, phenocopy, or low minor allele frequencies.

Original languageEnglish (US)
Pages (from-to)78-89
Number of pages12
JournalAnnals of Human Genetics
Volume75
Issue number1
DOIs
StatePublished - Jan 2011

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)

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