Model for mapping imprinted quantitative trait loci in an inbred F 2 design

Yuehua Cui, Qing Lu, James M. Cheverud, Ramon C. Littell, Rongling Wu

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

The role of imprinting in shaping development has been ubiquitously observed in plants, animals, and humans. However, a statistical method that can detect and estimate the effects of imprinted quantitative trait loci (iQTL) over the genome has not been extensively developed. In this article, we propose a maximum likelihood approach for testing and estimating the imprinted effects of iQTL that contribute to variation in a quantitative trait. This approach, implemented with the EM algorithm, allows for a genome-wide scan for the existence of iQTL. This approach was used to reanalyze published data in an F2 family derived from the LG/S and SM/S mouse strains. Several iQTL that regulate the growth of body weight by expressing paternally inherited alleles were identified. Our approach provides a standard procedure for testing the statistical significance of iQTL involved in the genetic control of complex traits.

Original languageEnglish (US)
Pages (from-to)543-551
Number of pages9
JournalGenomics
Volume87
Issue number4
DOIs
StatePublished - Apr 1 2006

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Quantitative Trait Loci
Genome
Alleles
Body Weight
Growth

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

Cui, Yuehua ; Lu, Qing ; Cheverud, James M. ; Littell, Ramon C. ; Wu, Rongling. / Model for mapping imprinted quantitative trait loci in an inbred F 2 design. In: Genomics. 2006 ; Vol. 87, No. 4. pp. 543-551.
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Model for mapping imprinted quantitative trait loci in an inbred F 2 design. / Cui, Yuehua; Lu, Qing; Cheverud, James M.; Littell, Ramon C.; Wu, Rongling.

In: Genomics, Vol. 87, No. 4, 01.04.2006, p. 543-551.

Research output: Contribution to journalArticle

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