Model for self-polarization and motility of keratocyte fragments

Falko Ziebert, Sumanth Swaminathan, Igor Aronson

Research output: Contribution to journalArticle

91 Citations (Scopus)

Abstract

Computational modelling of cell motility on substrates is a formidable challenge; regulatory pathways are intertwined and forces that influence cell motion are not fully quantified. Additional challenges arise from the need to describe a moving deformable cell boundary. Here, we present a simple mathematical model coupling cell shape dynamics, treated by the phase-field approach, to a vector field describing the mean orientation (polarization) of the actin filament network. The model successfully reproduces the primary phenomenology of cell motility: discontinuous onset of motion, diversity of cell shapes and shape oscillations. The results are in qualitative agreement with recent experiments on motility of keratocyte cells and cell fragments. The asymmetry of the shapes is captured to a large extent in this simple model, which may prove useful for the interpretation of experiments.

Original languageEnglish (US)
Pages (from-to)1084-1092
Number of pages9
JournalJournal of the Royal Society Interface
Volume9
Issue number70
DOIs
StatePublished - May 7 2012

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Cell Movement
Cell Shape
Polarization
Actins
Experiments
Mathematical models
Actin Cytoskeleton
Theoretical Models
Substrates

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biochemistry
  • Biomedical Engineering

Cite this

Ziebert, Falko ; Swaminathan, Sumanth ; Aronson, Igor. / Model for self-polarization and motility of keratocyte fragments. In: Journal of the Royal Society Interface. 2012 ; Vol. 9, No. 70. pp. 1084-1092.
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Model for self-polarization and motility of keratocyte fragments. / Ziebert, Falko; Swaminathan, Sumanth; Aronson, Igor.

In: Journal of the Royal Society Interface, Vol. 9, No. 70, 07.05.2012, p. 1084-1092.

Research output: Contribution to journalArticle

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