Model studies on total synthesis of the chartellines, spirocyclic β-lactam alkaloids from a marine bryozoan

Xichen Lin, Steven M. Weinreb

Research output: Contribution to journalArticle

51 Scopus citations

Abstract

A chartelline alkaloid model system containing a spirocyclic β-lactam moiety and α,β-unsaturated imine has been constructed from isatin using a Staudinger imine-ketene cycloaddition and an addition to an N-activated γ-lactam as key steps.

Original languageEnglish (US)
Pages (from-to)2631-2633
Number of pages3
JournalTetrahedron Letters
Volume42
Issue number14
DOIs
StatePublished - Apr 2 2001

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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