Modeling of variational gradient porous architecture with multidirectional filament deposition in 3D scaffolds

A. K.M. Khoda, Ibrahim Tarik Ozbolat, Bahattin Koc

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Porous scaffolds with interconnected and continuous pores have recently been developed to stimulate tissue regeneration. Even though few researches have focused on the internal architecture of porous scaffolds but concluded that properly interconnected and continuous pores with spatial distribution might perform diverse mechanical, biological and chemical functions of a scaffold. Thus the need for reproducible and fabricatable scaffold design with controllable gradient porosity is obvious but is hardly achieved because of design and fabrication limitations. In this paper, a novel functionally gradient variational porosity architecture has been proposed with continuous material deposition planning scheme. The medial axis transformation for the scaffold has been calculated to generate an internal feature of the geometric domain. The medial axis is then used as a base to develop the medial boundary to define the medial regions. Then the complex internal architecture of scaffolds is divided into sub-regions using the ruling lines that are generated between the slice's contour and the medial boundary. The desired controlled variational porosity along the scaffold architecture has been achieved with the combination of two geometrically oriented consecutive layers while meeting the tissue scaffold design constraints. This ensures truly porous structures in every direction as well as controllable porosity with interconnected pores along the scaffold architecture. The proposed methodology has been implemented and illustrative examples are also provided. A sample designed structure has been fabricated with a NC motion controlled micro-nozzle deposition system.

Original languageEnglish (US)
Pages (from-to)445-459
Number of pages15
JournalComputer-Aided Design and Applications
Volume10
Issue number3
DOIs
StatePublished - Jan 14 2013

Fingerprint

Scaffold
Filament
Scaffolds
Gradient
Modeling
Porosity
Medial Axis
Internal
Tissue regeneration
Architecture
Regeneration
Nozzle
Spatial distribution
Spatial Distribution
Slice
Nozzles
Consecutive
Fabrication
Planning
Motion

All Science Journal Classification (ASJC) codes

  • Computational Mechanics
  • Computer Graphics and Computer-Aided Design
  • Computational Mathematics

Cite this

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Modeling of variational gradient porous architecture with multidirectional filament deposition in 3D scaffolds. / Khoda, A. K.M.; Ozbolat, Ibrahim Tarik; Koc, Bahattin.

In: Computer-Aided Design and Applications, Vol. 10, No. 3, 14.01.2013, p. 445-459.

Research output: Contribution to journalArticle

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