Modeling the electric field effects on heterogeneous Pinsky-Rinzel neurons under ephaptic transmission

Xile Wei, Yinhong Chen, Jiang Wang, Bin Deng, Meili Lu, Yanqiu Che

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Pinsky-Rinzel (PR) field effect models under ephaptic transmission both in a single neuron and coupling neurons are constructed and studied in this paper. In presence of electric field, the extracellular media have already shown to play a constructive role in neuronal system. Different from the physical synapses, the ephapse is dependent on the conductive property of the extracellular media. Under the ephaptic transmission, the electric field strength, the extracellular media and concentration of extracellular potassium ion has great influence on neuronal firing behavior. In the analysis of heterogeneous coupling neurons, applied the same electric field, the smaller heterogeneity, the stronger synchronicity in coupling neurons and with the concentration of extracellular potassium ion increasing in a certain range, the more synchronous phenomenon is observed. These agree with some epileptic seizure experiments in low calcium solution. It is interesting that for smaller heterogeneous coupling neurons, both the larger negative and positive field may lead to synchronicity and for bigger heterogeneous coupling neurons only the larger negative field can synchronize the neurons.

Original languageEnglish (US)
Title of host publicationProceedings of the 2012 24th Chinese Control and Decision Conference, CCDC 2012
Pages1178-1183
Number of pages6
DOIs
StatePublished - Oct 1 2012
Event2012 24th Chinese Control and Decision Conference, CCDC 2012 - Taiyuan, China
Duration: May 23 2012May 25 2012

Other

Other2012 24th Chinese Control and Decision Conference, CCDC 2012
CountryChina
CityTaiyuan
Period5/23/125/25/12

Fingerprint

Electric field effects
Neurons
Electric fields
Potassium
Ions
Neuron
Modeling
Calcium

All Science Journal Classification (ASJC) codes

  • Information Systems and Management
  • Control and Systems Engineering

Cite this

Wei, X., Chen, Y., Wang, J., Deng, B., Lu, M., & Che, Y. (2012). Modeling the electric field effects on heterogeneous Pinsky-Rinzel neurons under ephaptic transmission. In Proceedings of the 2012 24th Chinese Control and Decision Conference, CCDC 2012 (pp. 1178-1183). [6244188] https://doi.org/10.1109/CCDC.2012.6244188
Wei, Xile ; Chen, Yinhong ; Wang, Jiang ; Deng, Bin ; Lu, Meili ; Che, Yanqiu. / Modeling the electric field effects on heterogeneous Pinsky-Rinzel neurons under ephaptic transmission. Proceedings of the 2012 24th Chinese Control and Decision Conference, CCDC 2012. 2012. pp. 1178-1183
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Wei, X, Chen, Y, Wang, J, Deng, B, Lu, M & Che, Y 2012, Modeling the electric field effects on heterogeneous Pinsky-Rinzel neurons under ephaptic transmission. in Proceedings of the 2012 24th Chinese Control and Decision Conference, CCDC 2012., 6244188, pp. 1178-1183, 2012 24th Chinese Control and Decision Conference, CCDC 2012, Taiyuan, China, 5/23/12. https://doi.org/10.1109/CCDC.2012.6244188

Modeling the electric field effects on heterogeneous Pinsky-Rinzel neurons under ephaptic transmission. / Wei, Xile; Chen, Yinhong; Wang, Jiang; Deng, Bin; Lu, Meili; Che, Yanqiu.

Proceedings of the 2012 24th Chinese Control and Decision Conference, CCDC 2012. 2012. p. 1178-1183 6244188.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Wei X, Chen Y, Wang J, Deng B, Lu M, Che Y. Modeling the electric field effects on heterogeneous Pinsky-Rinzel neurons under ephaptic transmission. In Proceedings of the 2012 24th Chinese Control and Decision Conference, CCDC 2012. 2012. p. 1178-1183. 6244188 https://doi.org/10.1109/CCDC.2012.6244188