Modeling the geometry, hemodynamics and tissue mechanics of cerebral aneurysms

Baoshun Ma, Jia Lu, Robert Harbaugh, Madhavan Raghavan

Research output: Contribution to journalConference article

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Abstract

The relationship between cerebral aneurysm geometry and biomechanics was investigated Human cerebral aneurysm geometry was reconstructed from computed tomography angiography (CTA) and refined. Various indices of global geometric (size and shape) features were computed based on differential and computational geometry techniques. Computational fluid dynamics (CFD) simulations were performed to model both steady and pulsatile blood flow in the aneurysm and surrounding vasculature. Hemodynamic indices such as wall shear stress, pressure and particle residence time were obtained. Nonlinear finite element method (FEM) and a reported finite strain constitutive model were employed to estimate the distribution of mechanical stress in the aneurysm wall under static pressure. Shear stress, sac pressure and mechanical stress correlated better with lesion shape while particle residence time correlated better with lesion size.

Original languageEnglish (US)
Article numberIMECE2004-60024
Pages (from-to)397-398
Number of pages2
JournalAdvances in Bioengineering, BED
Publication statusPublished - Jan 1 2004
Event2004 ASME International Mechanical Engineering Congress and Exposition, IMECE - Anaheim, CA, United States
Duration: Nov 13 2004Nov 19 2004

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All Science Journal Classification (ASJC) codes

  • Engineering(all)

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