Moderate alcohol consumption and levels of antioxidant vitamins and isoprostanes in postmenopausal women

Terryl Johnson Hartman, D. J. Baer, L. B. Graham, W. L. Stone, E. W. Gunter, C. E. Parker, P. S. Albert, J. F. Dorgan, B. A. Clevidence, W. S. Campbell, K. B. Tomer, J. T. Judd, P. R. Taylor

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Abstract

Background: Although alcohol intake has been positively associated with breast cancer risk in epidemiologic studies, the mechanisms mediating this association are speculative. Objective: The Postmenopausal Women's Alcohol Study was designed to explore the effects of moderate alcohol consumption on potential risk factors for breast cancer. In the present analysis, we evaluated the relationship of alcohol consumption with antioxidant nutrients and a biomarker of oxidative stress. Design: Participants (n = 53) consumed a controlled diet plus each of three treatments (15 or 30 g alcohol/day or a no-alcohol placebo beverage), during three 8-week periods in random order. We measured the antioxidants, vitamin E (alpha (α)- and gamma (γ-tocopherols), selenium, and vitamin C in fasting blood samples which were collected at the end of diet periods, treated and frozen for assay at the end of the study. We also measured 15-F2t-IsoP isoprostane, produced by lipid peroxidation, which serves as an indicator of oxidative stress and may serve as a biomarker for conditions favorable to carcinogenesis. Results: After adjusting for BMI (all models) and total serum cholesterol (tocopherol and isoprostane models) we observed a significant 4.6% decrease (P=0.02) in α-tocopherol and a marginally significant 4.9% increase (P = 0.07) in isoprostane levels when women consumed 30 g alcohol/day (P = 0.06 and 0.05 for overall effect of alcohol on α-tocopherol and isoprostanes, respectively). The other antioxidants were not significantly modified by the alcohol treatment. Conclusions: These results suggest that moderate alcohol consumption increases some biomarkers of oxidative stress in postmenopausal women.

Original languageEnglish (US)
Pages (from-to)161-168
Number of pages8
JournalEuropean Journal of Clinical Nutrition
Volume59
Issue number2
DOIs
StatePublished - Feb 1 2005

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Isoprostanes
Vitamins
Alcohol Drinking
Antioxidants
Alcohols
Tocopherols
Oxidative Stress
Biomarkers
gamma-Tocopherol
Breast Neoplasms
Diet
Beverages
alpha-Tocopherol
Selenium
Vitamin E
Lipid Peroxidation
Ascorbic Acid
Epidemiologic Studies
Fasting
Carcinogenesis

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Hartman, T. J., Baer, D. J., Graham, L. B., Stone, W. L., Gunter, E. W., Parker, C. E., ... Taylor, P. R. (2005). Moderate alcohol consumption and levels of antioxidant vitamins and isoprostanes in postmenopausal women. European Journal of Clinical Nutrition, 59(2), 161-168. https://doi.org/10.1038/sj.ejcn.1602051
Hartman, Terryl Johnson ; Baer, D. J. ; Graham, L. B. ; Stone, W. L. ; Gunter, E. W. ; Parker, C. E. ; Albert, P. S. ; Dorgan, J. F. ; Clevidence, B. A. ; Campbell, W. S. ; Tomer, K. B. ; Judd, J. T. ; Taylor, P. R. / Moderate alcohol consumption and levels of antioxidant vitamins and isoprostanes in postmenopausal women. In: European Journal of Clinical Nutrition. 2005 ; Vol. 59, No. 2. pp. 161-168.
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abstract = "Background: Although alcohol intake has been positively associated with breast cancer risk in epidemiologic studies, the mechanisms mediating this association are speculative. Objective: The Postmenopausal Women's Alcohol Study was designed to explore the effects of moderate alcohol consumption on potential risk factors for breast cancer. In the present analysis, we evaluated the relationship of alcohol consumption with antioxidant nutrients and a biomarker of oxidative stress. Design: Participants (n = 53) consumed a controlled diet plus each of three treatments (15 or 30 g alcohol/day or a no-alcohol placebo beverage), during three 8-week periods in random order. We measured the antioxidants, vitamin E (alpha (α)- and gamma (γ-tocopherols), selenium, and vitamin C in fasting blood samples which were collected at the end of diet periods, treated and frozen for assay at the end of the study. We also measured 15-F2t-IsoP isoprostane, produced by lipid peroxidation, which serves as an indicator of oxidative stress and may serve as a biomarker for conditions favorable to carcinogenesis. Results: After adjusting for BMI (all models) and total serum cholesterol (tocopherol and isoprostane models) we observed a significant 4.6{\%} decrease (P=0.02) in α-tocopherol and a marginally significant 4.9{\%} increase (P = 0.07) in isoprostane levels when women consumed 30 g alcohol/day (P = 0.06 and 0.05 for overall effect of alcohol on α-tocopherol and isoprostanes, respectively). The other antioxidants were not significantly modified by the alcohol treatment. Conclusions: These results suggest that moderate alcohol consumption increases some biomarkers of oxidative stress in postmenopausal women.",
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Hartman, TJ, Baer, DJ, Graham, LB, Stone, WL, Gunter, EW, Parker, CE, Albert, PS, Dorgan, JF, Clevidence, BA, Campbell, WS, Tomer, KB, Judd, JT & Taylor, PR 2005, 'Moderate alcohol consumption and levels of antioxidant vitamins and isoprostanes in postmenopausal women', European Journal of Clinical Nutrition, vol. 59, no. 2, pp. 161-168. https://doi.org/10.1038/sj.ejcn.1602051

Moderate alcohol consumption and levels of antioxidant vitamins and isoprostanes in postmenopausal women. / Hartman, Terryl Johnson; Baer, D. J.; Graham, L. B.; Stone, W. L.; Gunter, E. W.; Parker, C. E.; Albert, P. S.; Dorgan, J. F.; Clevidence, B. A.; Campbell, W. S.; Tomer, K. B.; Judd, J. T.; Taylor, P. R.

In: European Journal of Clinical Nutrition, Vol. 59, No. 2, 01.02.2005, p. 161-168.

Research output: Contribution to journalArticle

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T1 - Moderate alcohol consumption and levels of antioxidant vitamins and isoprostanes in postmenopausal women

AU - Hartman, Terryl Johnson

AU - Baer, D. J.

AU - Graham, L. B.

AU - Stone, W. L.

AU - Gunter, E. W.

AU - Parker, C. E.

AU - Albert, P. S.

AU - Dorgan, J. F.

AU - Clevidence, B. A.

AU - Campbell, W. S.

AU - Tomer, K. B.

AU - Judd, J. T.

AU - Taylor, P. R.

PY - 2005/2/1

Y1 - 2005/2/1

N2 - Background: Although alcohol intake has been positively associated with breast cancer risk in epidemiologic studies, the mechanisms mediating this association are speculative. Objective: The Postmenopausal Women's Alcohol Study was designed to explore the effects of moderate alcohol consumption on potential risk factors for breast cancer. In the present analysis, we evaluated the relationship of alcohol consumption with antioxidant nutrients and a biomarker of oxidative stress. Design: Participants (n = 53) consumed a controlled diet plus each of three treatments (15 or 30 g alcohol/day or a no-alcohol placebo beverage), during three 8-week periods in random order. We measured the antioxidants, vitamin E (alpha (α)- and gamma (γ-tocopherols), selenium, and vitamin C in fasting blood samples which were collected at the end of diet periods, treated and frozen for assay at the end of the study. We also measured 15-F2t-IsoP isoprostane, produced by lipid peroxidation, which serves as an indicator of oxidative stress and may serve as a biomarker for conditions favorable to carcinogenesis. Results: After adjusting for BMI (all models) and total serum cholesterol (tocopherol and isoprostane models) we observed a significant 4.6% decrease (P=0.02) in α-tocopherol and a marginally significant 4.9% increase (P = 0.07) in isoprostane levels when women consumed 30 g alcohol/day (P = 0.06 and 0.05 for overall effect of alcohol on α-tocopherol and isoprostanes, respectively). The other antioxidants were not significantly modified by the alcohol treatment. Conclusions: These results suggest that moderate alcohol consumption increases some biomarkers of oxidative stress in postmenopausal women.

AB - Background: Although alcohol intake has been positively associated with breast cancer risk in epidemiologic studies, the mechanisms mediating this association are speculative. Objective: The Postmenopausal Women's Alcohol Study was designed to explore the effects of moderate alcohol consumption on potential risk factors for breast cancer. In the present analysis, we evaluated the relationship of alcohol consumption with antioxidant nutrients and a biomarker of oxidative stress. Design: Participants (n = 53) consumed a controlled diet plus each of three treatments (15 or 30 g alcohol/day or a no-alcohol placebo beverage), during three 8-week periods in random order. We measured the antioxidants, vitamin E (alpha (α)- and gamma (γ-tocopherols), selenium, and vitamin C in fasting blood samples which were collected at the end of diet periods, treated and frozen for assay at the end of the study. We also measured 15-F2t-IsoP isoprostane, produced by lipid peroxidation, which serves as an indicator of oxidative stress and may serve as a biomarker for conditions favorable to carcinogenesis. Results: After adjusting for BMI (all models) and total serum cholesterol (tocopherol and isoprostane models) we observed a significant 4.6% decrease (P=0.02) in α-tocopherol and a marginally significant 4.9% increase (P = 0.07) in isoprostane levels when women consumed 30 g alcohol/day (P = 0.06 and 0.05 for overall effect of alcohol on α-tocopherol and isoprostanes, respectively). The other antioxidants were not significantly modified by the alcohol treatment. Conclusions: These results suggest that moderate alcohol consumption increases some biomarkers of oxidative stress in postmenopausal women.

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