Modification of a biventricular assist device to facilitate preservative infusion and organ recovery in a nonheart-beating donor

Ron Angona, Peter Abt, Duraid Younan, Todd Massey, Michael Marvin, Randeep Kashyap, Dan Richards, Karen Jones, James Queschenbach, Martin Zand, Ashokkumar Jain, Mark Orloff, Adel Bozorgzadeh

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A 46-year-old patient supported by a biventricular assist device (BiVAD) was transferred to our institution for evaluation for heart transplant. The patient was found to have a large intracranial hemorrhage with profound deterioration of neurologic status. The poor prognosis prompted the decision to withdraw care and pursue organ donation. Because the patient did not meet brain death criteria, nonheart-beating donor organ donation was pursued. After the termination of care, the BiVAD was modified: the left side to provide organ preservative solution and the right side to allow drainage. Eight liters of cold University of Wisconsin solution were pumped systemically over 10 minutes, the donor was drained, and the liver was harvested. This technique expedited donor perfusion by eliminating the need to cannulate, minimizing ischemic time for the liver. Although the recipient outcome was poor, and retransplantation was eventually necessary, we believe it was most likely not attributable to the quality of organ preservation. This report discusses the technical aspects of this potentially beneficial procedure.

Original languageEnglish (US)
Pages (from-to)157-160
Number of pages4
JournalJournal of Extra-Corporeal Technology
Volume38
Issue number2
StatePublished - Jun 2006

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Tissue and Organ Procurement
Tissue Donors
Equipment and Supplies
Organ Preservation
Brain Death
Intracranial Hemorrhages
Liver
Nervous System
Drainage
Perfusion
Transplants

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)

Cite this

Angona, R., Abt, P., Younan, D., Massey, T., Marvin, M., Kashyap, R., ... Bozorgzadeh, A. (2006). Modification of a biventricular assist device to facilitate preservative infusion and organ recovery in a nonheart-beating donor. Journal of Extra-Corporeal Technology, 38(2), 157-160.
Angona, Ron ; Abt, Peter ; Younan, Duraid ; Massey, Todd ; Marvin, Michael ; Kashyap, Randeep ; Richards, Dan ; Jones, Karen ; Queschenbach, James ; Zand, Martin ; Jain, Ashokkumar ; Orloff, Mark ; Bozorgzadeh, Adel. / Modification of a biventricular assist device to facilitate preservative infusion and organ recovery in a nonheart-beating donor. In: Journal of Extra-Corporeal Technology. 2006 ; Vol. 38, No. 2. pp. 157-160.
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abstract = "A 46-year-old patient supported by a biventricular assist device (BiVAD) was transferred to our institution for evaluation for heart transplant. The patient was found to have a large intracranial hemorrhage with profound deterioration of neurologic status. The poor prognosis prompted the decision to withdraw care and pursue organ donation. Because the patient did not meet brain death criteria, nonheart-beating donor organ donation was pursued. After the termination of care, the BiVAD was modified: the left side to provide organ preservative solution and the right side to allow drainage. Eight liters of cold University of Wisconsin solution were pumped systemically over 10 minutes, the donor was drained, and the liver was harvested. This technique expedited donor perfusion by eliminating the need to cannulate, minimizing ischemic time for the liver. Although the recipient outcome was poor, and retransplantation was eventually necessary, we believe it was most likely not attributable to the quality of organ preservation. This report discusses the technical aspects of this potentially beneficial procedure.",
author = "Ron Angona and Peter Abt and Duraid Younan and Todd Massey and Michael Marvin and Randeep Kashyap and Dan Richards and Karen Jones and James Queschenbach and Martin Zand and Ashokkumar Jain and Mark Orloff and Adel Bozorgzadeh",
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Angona, R, Abt, P, Younan, D, Massey, T, Marvin, M, Kashyap, R, Richards, D, Jones, K, Queschenbach, J, Zand, M, Jain, A, Orloff, M & Bozorgzadeh, A 2006, 'Modification of a biventricular assist device to facilitate preservative infusion and organ recovery in a nonheart-beating donor', Journal of Extra-Corporeal Technology, vol. 38, no. 2, pp. 157-160.

Modification of a biventricular assist device to facilitate preservative infusion and organ recovery in a nonheart-beating donor. / Angona, Ron; Abt, Peter; Younan, Duraid; Massey, Todd; Marvin, Michael; Kashyap, Randeep; Richards, Dan; Jones, Karen; Queschenbach, James; Zand, Martin; Jain, Ashokkumar; Orloff, Mark; Bozorgzadeh, Adel.

In: Journal of Extra-Corporeal Technology, Vol. 38, No. 2, 06.2006, p. 157-160.

Research output: Contribution to journalArticle

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T1 - Modification of a biventricular assist device to facilitate preservative infusion and organ recovery in a nonheart-beating donor

AU - Angona, Ron

AU - Abt, Peter

AU - Younan, Duraid

AU - Massey, Todd

AU - Marvin, Michael

AU - Kashyap, Randeep

AU - Richards, Dan

AU - Jones, Karen

AU - Queschenbach, James

AU - Zand, Martin

AU - Jain, Ashokkumar

AU - Orloff, Mark

AU - Bozorgzadeh, Adel

PY - 2006/6

Y1 - 2006/6

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