Modular approach for modeling cell motility

F. Ziebert, I. S. Aranson

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Modeling cell movement is a challenging task since the motility machinery is highly complex. Moreover, there is a rather broad diversity of different cell types. In order to obtain insights into generic features of the motility mechanisms of several distinct cell types, we propose a modular approach that starts with a minimal model, consisting of a phase field description of the moving cell boundary and a simplified internal dynamics. We discuss how this starting point can be extended to increase the level of detail, and how the internal dynamics "module" can be changed/adjusted to properly model various cell types. The former route allows studying specific processes involved in cell motility in the framework of a self-organized moving domain, and the latter might permit to put different cellular motility mechanisms into a unified framework.

Original languageEnglish (US)
Pages (from-to)1265-1277
Number of pages13
JournalEuropean Physical Journal: Special Topics
Volume223
Issue number7
DOIs
StatePublished - Jan 1 2014

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Physics and Astronomy(all)
  • Physical and Theoretical Chemistry

Fingerprint Dive into the research topics of 'Modular approach for modeling cell motility'. Together they form a unique fingerprint.

Cite this