The use of synthetic biodegradable polymers as a means to tissue-engineer a functional endothelium on expanded polytetrafluoroethylene (ePTFE) grafts was investigated. It was shown that the biodegradable elastomer poly(1,8-octanediol citrate (POC) can confer improved biocompatibility characteristics on ePTFE vascular grafts without affecting graft compliance. It was observed that synthesis of POC can be conducted under relatively low temperatures without vacuum and catalysts. It was observed that POC modification can significantly improve the hemocompatibility and acute inflammatory response of ePTFE grafts implemented in a porcine iliac artery ePTFE bypass model. It was found that the POC interface confers hydrophilicity, reduces thrombogenicity, and reduces in vivo macrophage infiltration into the ePTFE grafts.
All Science Journal Classification (ASJC) codes
- Materials Science(all)
- Mechanics of Materials
- Mechanical Engineering