Modulation of Caenorhabditis elegans transcription factor activity by HIM-8 and the related zinc-finger ZIM proteins

Hongliu Sun, Brian L. Nelms, Sama F. Sleiman, Helen M. Chamberlin, Wendy Hanna-Rose

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The previously reported negative regulatory activity of HIM-8 on the Sox protein EGL-13 is shared by the HIM-8-related ZIM proteins. Furthermore, mutation of HIM-8 can modulate the effects of substitution mutations in the DNA-binding domains of at least four other transcription factors, suggesting broad regulatory activity by HIM-8.

Original languageEnglish (US)
Pages (from-to)1221-1226
Number of pages6
JournalGenetics
Volume177
Issue number2
DOIs
StatePublished - Oct 1 2007

Fingerprint

Zinc Fingers
Caenorhabditis elegans
Transcription Factors
Mutation
Proteins
DNA

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)

Cite this

Sun, Hongliu ; Nelms, Brian L. ; Sleiman, Sama F. ; Chamberlin, Helen M. ; Hanna-Rose, Wendy. / Modulation of Caenorhabditis elegans transcription factor activity by HIM-8 and the related zinc-finger ZIM proteins. In: Genetics. 2007 ; Vol. 177, No. 2. pp. 1221-1226.
@article{2ca942101e8240d09c2babc1df5d6d47,
title = "Modulation of Caenorhabditis elegans transcription factor activity by HIM-8 and the related zinc-finger ZIM proteins",
abstract = "The previously reported negative regulatory activity of HIM-8 on the Sox protein EGL-13 is shared by the HIM-8-related ZIM proteins. Furthermore, mutation of HIM-8 can modulate the effects of substitution mutations in the DNA-binding domains of at least four other transcription factors, suggesting broad regulatory activity by HIM-8.",
author = "Hongliu Sun and Nelms, {Brian L.} and Sleiman, {Sama F.} and Chamberlin, {Helen M.} and Wendy Hanna-Rose",
year = "2007",
month = "10",
day = "1",
doi = "10.1534/genetics.107.070847",
language = "English (US)",
volume = "177",
pages = "1221--1226",
journal = "Genetics",
issn = "0016-6731",
publisher = "Genetics Society of America",
number = "2",

}

Modulation of Caenorhabditis elegans transcription factor activity by HIM-8 and the related zinc-finger ZIM proteins. / Sun, Hongliu; Nelms, Brian L.; Sleiman, Sama F.; Chamberlin, Helen M.; Hanna-Rose, Wendy.

In: Genetics, Vol. 177, No. 2, 01.10.2007, p. 1221-1226.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Modulation of Caenorhabditis elegans transcription factor activity by HIM-8 and the related zinc-finger ZIM proteins

AU - Sun, Hongliu

AU - Nelms, Brian L.

AU - Sleiman, Sama F.

AU - Chamberlin, Helen M.

AU - Hanna-Rose, Wendy

PY - 2007/10/1

Y1 - 2007/10/1

N2 - The previously reported negative regulatory activity of HIM-8 on the Sox protein EGL-13 is shared by the HIM-8-related ZIM proteins. Furthermore, mutation of HIM-8 can modulate the effects of substitution mutations in the DNA-binding domains of at least four other transcription factors, suggesting broad regulatory activity by HIM-8.

AB - The previously reported negative regulatory activity of HIM-8 on the Sox protein EGL-13 is shared by the HIM-8-related ZIM proteins. Furthermore, mutation of HIM-8 can modulate the effects of substitution mutations in the DNA-binding domains of at least four other transcription factors, suggesting broad regulatory activity by HIM-8.

UR - http://www.scopus.com/inward/record.url?scp=35549006667&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=35549006667&partnerID=8YFLogxK

U2 - 10.1534/genetics.107.070847

DO - 10.1534/genetics.107.070847

M3 - Article

VL - 177

SP - 1221

EP - 1226

JO - Genetics

JF - Genetics

SN - 0016-6731

IS - 2

ER -