Modulation of Caenorhabditis elegans transcription factor activity by HIM-8 and the related zinc-finger ZIM proteins

Hongliu Sun, Brian L. Nelms, Sama F. Sleiman, Helen M. Chamberlin, Wendy Hanna-Rose

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

The previously reported negative regulatory activity of HIM-8 on the Sox protein EGL-13 is shared by the HIM-8-related ZIM proteins. Furthermore, mutation of HIM-8 can modulate the effects of substitution mutations in the DNA-binding domains of at least four other transcription factors, suggesting broad regulatory activity by HIM-8.

Original languageEnglish (US)
Pages (from-to)1221-1226
Number of pages6
JournalGenetics
Volume177
Issue number2
DOIs
StatePublished - Oct 2007

All Science Journal Classification (ASJC) codes

  • Genetics

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