Modulation of colon cancer by nutmeg

Fei Li, Xiu Wei Yang, Kristopher W. Krausz, Robert G. Nichols, Wei Xu, Andrew David Patterson, Frank J. Gonzalez

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Colon cancer is the most common cancer and the third leading cause of cancer mortality in humans. Using mass spectrometry-based metabolomics, the current study revealed the accumulation of four uremic toxins (cresol sulfate, cresol glucuronide, indoxyl sulfate, and phenyl sulfate) in the serum of mice harboring adenomatous polyposis coli (APC) gene mutation-induced colon cancer. These uremic toxins, likely generated from the gut microbiota, were associated with an increase in the expression of the proinflammatory cytokine IL-6 and a disorder of lipid metabolism. Nutmeg, which exhibits antimicrobial activity, attenuated the levels of uremic toxins and decreased intestinal tumorigenesis in Apcmin/+ mice. Nutmeg-treated Apcmin/+ mice had decreased IL-6 levels and normalized dysregulated lipid metabolism, suggesting that uremic toxins are responsible, in part, for the metabolic disorders that occur during tumorigenesis. These studies demonstrate a potential biochemical link among gut microbial metabolism, inflammation, and metabolic disorders and suggest that modulation of gut microbiota and lipid metabolism using dietary intervention or drugs may be effective in colon cancer chemoprevention strategies.

Original languageEnglish (US)
Pages (from-to)1937-1946
Number of pages10
JournalJournal of Proteome Research
Volume14
Issue number4
DOIs
StatePublished - Apr 3 2015

Fingerprint

Myristica fragrans
Colonic Neoplasms
cresol
Modulation
Lipid Metabolism
Interleukin-6
Carcinogenesis
Indican
Lipid Metabolism Disorders
APC Genes
Metabolomics
Glucuronides
Chemoprevention
Metabolism
Sulfates
Mass spectrometry
Mass Spectrometry
Neoplasms
Genes
Cytokines

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Chemistry(all)

Cite this

Li, F., Yang, X. W., Krausz, K. W., Nichols, R. G., Xu, W., Patterson, A. D., & Gonzalez, F. J. (2015). Modulation of colon cancer by nutmeg. Journal of Proteome Research, 14(4), 1937-1946. https://doi.org/10.1021/pr5013152
Li, Fei ; Yang, Xiu Wei ; Krausz, Kristopher W. ; Nichols, Robert G. ; Xu, Wei ; Patterson, Andrew David ; Gonzalez, Frank J. / Modulation of colon cancer by nutmeg. In: Journal of Proteome Research. 2015 ; Vol. 14, No. 4. pp. 1937-1946.
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Li, F, Yang, XW, Krausz, KW, Nichols, RG, Xu, W, Patterson, AD & Gonzalez, FJ 2015, 'Modulation of colon cancer by nutmeg', Journal of Proteome Research, vol. 14, no. 4, pp. 1937-1946. https://doi.org/10.1021/pr5013152

Modulation of colon cancer by nutmeg. / Li, Fei; Yang, Xiu Wei; Krausz, Kristopher W.; Nichols, Robert G.; Xu, Wei; Patterson, Andrew David; Gonzalez, Frank J.

In: Journal of Proteome Research, Vol. 14, No. 4, 03.04.2015, p. 1937-1946.

Research output: Contribution to journalArticle

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Li F, Yang XW, Krausz KW, Nichols RG, Xu W, Patterson AD et al. Modulation of colon cancer by nutmeg. Journal of Proteome Research. 2015 Apr 3;14(4):1937-1946. https://doi.org/10.1021/pr5013152