Modulation of gastrointestinal inflammation and colorectal tumorigenesis by peroxisome proliferator-activated receptor-β/δ (PPARβ/δ)

Jeffrey M. Peters, Jose L. Morales, Frank J. Gonzalez

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations

Abstract

Critical physiological roles of peroxisome proliferatoractivated receptor-β/δ (PPARβ/δ) include the regulation glucose and lipid homeostasis, cellular differentiation and modulation of inflammation. The potential for targeting PPARβ/δ for the prevention and treatment of metabolic diseases or cancer, is compromised because of major inconsistencies in the literature. This is due primarily to uncertainty regarding the effect of PPARβ/δ and its activation on cell proliferation, apoptosis and cell survival. This review summarizes both the confirmed and conflicting mechanisms that have been described for PPARβ/δ and the potential for targeting this nuclear receptor for the prevention and treatment of colon cancer.

Original languageEnglish (US)
Pages (from-to)e85-e93
JournalDrug Discovery Today: Disease Mechanisms
Volume8
Issue number3-4
DOIs
StatePublished - 2011

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Drug Discovery

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