Modulation of neuronal input-output function by subthreshold electric fields from dendritic sublinear integration

Yaqin Fan, Xile Wei, Meili Lu, Jiang Wang, Guosheng Yi, Yanqiu Che

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Electrical field (EF) is a popular tool for both basic research and clinical applications, its actions on neuronal activities have been investigated from physiological mechanism and dynamics. However, few studies explore its modulatory influence on neuronal computation from the point of view of dendritic sublinear integration caused by passive dendrites which play an important role in neuronal computation. Here with a reduced biophysical model this problem is explained by observing the impact of EF on neuronal computation and dendritic sublinear operation. It is found that the positive EF results in more linear dendritic sublinear integration because of hyperpolarization in distal dendrites together resulting in higher neuronal excitability in neuronal computation but negative EF inhibits this ability due to more pronounced dendritic sublinear operation resulting from the hyperpolarization in distal dendrites. Further, we explain the modulation of positive EF on dysfunctional neuron combining with Feature Binding Problem. This work builds the gap between neuronal computation and dendritic sublinear operation, which is helpful to understand the modulation of EFs on brain functions.

Original languageEnglish (US)
Title of host publication9th International IEEE EMBS Conference on Neural Engineering, NER 2019
PublisherIEEE Computer Society
Pages397-400
Number of pages4
ISBN (Electronic)9781538679210
DOIs
StatePublished - May 16 2019
Event9th International IEEE EMBS Conference on Neural Engineering, NER 2019 - San Francisco, United States
Duration: Mar 20 2019Mar 23 2019

Publication series

NameInternational IEEE/EMBS Conference on Neural Engineering, NER
Volume2019-March
ISSN (Print)1948-3546
ISSN (Electronic)1948-3554

Conference

Conference9th International IEEE EMBS Conference on Neural Engineering, NER 2019
CountryUnited States
CitySan Francisco
Period3/20/193/23/19

Fingerprint

Electric fields
Modulation
Neurons
Brain

All Science Journal Classification (ASJC) codes

  • Artificial Intelligence
  • Mechanical Engineering

Cite this

Fan, Y., Wei, X., Lu, M., Wang, J., Yi, G., & Che, Y. (2019). Modulation of neuronal input-output function by subthreshold electric fields from dendritic sublinear integration. In 9th International IEEE EMBS Conference on Neural Engineering, NER 2019 (pp. 397-400). [8716930] (International IEEE/EMBS Conference on Neural Engineering, NER; Vol. 2019-March). IEEE Computer Society. https://doi.org/10.1109/NER.2019.8716930
Fan, Yaqin ; Wei, Xile ; Lu, Meili ; Wang, Jiang ; Yi, Guosheng ; Che, Yanqiu. / Modulation of neuronal input-output function by subthreshold electric fields from dendritic sublinear integration. 9th International IEEE EMBS Conference on Neural Engineering, NER 2019. IEEE Computer Society, 2019. pp. 397-400 (International IEEE/EMBS Conference on Neural Engineering, NER).
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Fan, Y, Wei, X, Lu, M, Wang, J, Yi, G & Che, Y 2019, Modulation of neuronal input-output function by subthreshold electric fields from dendritic sublinear integration. in 9th International IEEE EMBS Conference on Neural Engineering, NER 2019., 8716930, International IEEE/EMBS Conference on Neural Engineering, NER, vol. 2019-March, IEEE Computer Society, pp. 397-400, 9th International IEEE EMBS Conference on Neural Engineering, NER 2019, San Francisco, United States, 3/20/19. https://doi.org/10.1109/NER.2019.8716930

Modulation of neuronal input-output function by subthreshold electric fields from dendritic sublinear integration. / Fan, Yaqin; Wei, Xile; Lu, Meili; Wang, Jiang; Yi, Guosheng; Che, Yanqiu.

9th International IEEE EMBS Conference on Neural Engineering, NER 2019. IEEE Computer Society, 2019. p. 397-400 8716930 (International IEEE/EMBS Conference on Neural Engineering, NER; Vol. 2019-March).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Fan Y, Wei X, Lu M, Wang J, Yi G, Che Y. Modulation of neuronal input-output function by subthreshold electric fields from dendritic sublinear integration. In 9th International IEEE EMBS Conference on Neural Engineering, NER 2019. IEEE Computer Society. 2019. p. 397-400. 8716930. (International IEEE/EMBS Conference on Neural Engineering, NER). https://doi.org/10.1109/NER.2019.8716930