Molecular analysis of imipenem-resistant Acinetobacter baumannii isolated from US service members wounded in Iraq, 2003-2008

X. Z. Huang, M. A. Chahine, J. G. Frye, D. M. Cash, E. P. Lesho, D. W. Craft, L. E. Lindler, M. P. Nikolich

Research output: Contribution to journalReview article

13 Citations (Scopus)

Abstract

Global dissemination of imipenem-resistant (IR) clones of Acinetobacter baumannii - A. calcoaceticus complex (ABC) have been frequently reported but the molecular epidemiological features of IR-ABC in military treatment facilities (MTFs) have not been described. We characterized 46 IR-ABC strains from a dataset of 298 ABC isolates collected from US service members hospitalized in different US MTFs domestically and overseas during 2003-2008. All IR strains carried the bla OXA-51 gene and 40 also carried bla OXA-23 on plasmids and/or chromosome; one carried bla OXA-58 and four contained ISAbal located upstream of bla OXA-51. Strains tended to cluster by pulsed-field gel electrophoresis profiles in time and location. Strains from two major clusters were identified as international clone I by multilocus sequence typing.

Original languageEnglish (US)
Pages (from-to)2302-2307
Number of pages6
JournalEpidemiology and Infection
Volume140
Issue number12
DOIs
StatePublished - Dec 1 2012

Fingerprint

Acinetobacter baumannii
Iraq
Imipenem
Military Facilities
Clone Cells
Multilocus Sequence Typing
Pulsed Field Gel Electrophoresis
Plasmids
Chromosomes
Asp(5)-oxytocin
Genes

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Infectious Diseases

Cite this

Huang, X. Z. ; Chahine, M. A. ; Frye, J. G. ; Cash, D. M. ; Lesho, E. P. ; Craft, D. W. ; Lindler, L. E. ; Nikolich, M. P. / Molecular analysis of imipenem-resistant Acinetobacter baumannii isolated from US service members wounded in Iraq, 2003-2008. In: Epidemiology and Infection. 2012 ; Vol. 140, No. 12. pp. 2302-2307.
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Molecular analysis of imipenem-resistant Acinetobacter baumannii isolated from US service members wounded in Iraq, 2003-2008. / Huang, X. Z.; Chahine, M. A.; Frye, J. G.; Cash, D. M.; Lesho, E. P.; Craft, D. W.; Lindler, L. E.; Nikolich, M. P.

In: Epidemiology and Infection, Vol. 140, No. 12, 01.12.2012, p. 2302-2307.

Research output: Contribution to journalReview article

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