Metodologie molecolari e genetiche nello studio degli effetti di agenti occupazionali ed ambientali: L'esempio del "seveso molecular epidemiology project"

Translated title of the contribution: Molecular and genetic methods for studying the effects of occupational and environmental agents: The seveso molecular epidemiology project

A. Baccarelli, A. Pesatori, D. Consonni, Donald George Jr Patterson, M. Bonzini, B. Marinelli, J. A. Grassman, P. A. Bertazzi, M. T. Landi

Research output: Contribution to journalArticle

Abstract

In 1997, IARC classified 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) as carcinogenic to humans, based on sufficient evidence from animal data and limited evidence from human data. A key role in the IARC classification was played by the well-defined mechanism of TCDD action involving the activation of the Arylhydrocarbon Receptor (AhR). Experimental animal and in-vitro studies indicate that AhR levels decrease following TCDD binding. Nearly 20 years after the Seveso accident, we found a decrease in AhR mRNA levels in TCDD-exposed subjects. AhR transcript levels were correlated with plasma TCDD concentrations. Our results may reflect a down-regulation of AhR, similar to that observed in most receptorial systems. We demonstrated, for the first time in humans, that TCDD-related regulation of the AhR pathway, previously observed in experimental studies, may also occur in exposed subjects. Our data are important for extrapolating AhR-mediated effects from experimental models to humans.

Translated title of the contributionMolecular and genetic methods for studying the effects of occupational and environmental agents: The seveso molecular epidemiology project
Original languageItalian
Pages (from-to)22-23
Number of pages2
JournalGiornale Italiano di Medicina del Lavoro ed Ergonomia
Volume26
Issue number4 SUPPL.
StatePublished - Nov 26 2004

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health

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    Baccarelli, A., Pesatori, A., Consonni, D., Patterson, D. G. J., Bonzini, M., Marinelli, B., Grassman, J. A., Bertazzi, P. A., & Landi, M. T. (2004). Metodologie molecolari e genetiche nello studio degli effetti di agenti occupazionali ed ambientali: L'esempio del "seveso molecular epidemiology project". Giornale Italiano di Medicina del Lavoro ed Ergonomia, 26(4 SUPPL.), 22-23.