Metodologie molecolari e genetiche nello studio degli effetti di agenti occupazionali ed ambientali: L'esempio del "seveso molecular epidemiology project"

Translated title of the contribution: Molecular and genetic methods for studying the effects of occupational and environmental agents: The seveso molecular epidemiology project

A. Baccarelli, A. Pesatori, D. Consonni, Donald George Jr Patterson, M. Bonzini, B. Marinelli, J. A. Grassman, P. A. Bertazzi, M. T. Landi

Research output: Contribution to journalArticle

Abstract

In 1997, IARC classified 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) as carcinogenic to humans, based on sufficient evidence from animal data and limited evidence from human data. A key role in the IARC classification was played by the well-defined mechanism of TCDD action involving the activation of the Arylhydrocarbon Receptor (AhR). Experimental animal and in-vitro studies indicate that AhR levels decrease following TCDD binding. Nearly 20 years after the Seveso accident, we found a decrease in AhR mRNA levels in TCDD-exposed subjects. AhR transcript levels were correlated with plasma TCDD concentrations. Our results may reflect a down-regulation of AhR, similar to that observed in most receptorial systems. We demonstrated, for the first time in humans, that TCDD-related regulation of the AhR pathway, previously observed in experimental studies, may also occur in exposed subjects. Our data are important for extrapolating AhR-mediated effects from experimental models to humans.

Original languageItalian
Pages (from-to)22-23
Number of pages2
JournalGiornale Italiano di Medicina del Lavoro ed Ergonomia
Volume26
Issue number4 SUPPL.
StatePublished - Nov 26 2004

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Molecular Epidemiology
Molecular Biology
Accidents
Polychlorinated Dibenzodioxins
Theoretical Models
Down-Regulation
Messenger RNA

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health

Cite this

Baccarelli, A., Pesatori, A., Consonni, D., Patterson, D. G. J., Bonzini, M., Marinelli, B., ... Landi, M. T. (2004). Metodologie molecolari e genetiche nello studio degli effetti di agenti occupazionali ed ambientali: L'esempio del "seveso molecular epidemiology project". Giornale Italiano di Medicina del Lavoro ed Ergonomia, 26(4 SUPPL.), 22-23.
Baccarelli, A. ; Pesatori, A. ; Consonni, D. ; Patterson, Donald George Jr ; Bonzini, M. ; Marinelli, B. ; Grassman, J. A. ; Bertazzi, P. A. ; Landi, M. T. / Metodologie molecolari e genetiche nello studio degli effetti di agenti occupazionali ed ambientali : L'esempio del "seveso molecular epidemiology project". In: Giornale Italiano di Medicina del Lavoro ed Ergonomia. 2004 ; Vol. 26, No. 4 SUPPL. pp. 22-23.
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Baccarelli, A, Pesatori, A, Consonni, D, Patterson, DGJ, Bonzini, M, Marinelli, B, Grassman, JA, Bertazzi, PA & Landi, MT 2004, 'Metodologie molecolari e genetiche nello studio degli effetti di agenti occupazionali ed ambientali: L'esempio del "seveso molecular epidemiology project"', Giornale Italiano di Medicina del Lavoro ed Ergonomia, vol. 26, no. 4 SUPPL., pp. 22-23.

Metodologie molecolari e genetiche nello studio degli effetti di agenti occupazionali ed ambientali : L'esempio del "seveso molecular epidemiology project". / Baccarelli, A.; Pesatori, A.; Consonni, D.; Patterson, Donald George Jr; Bonzini, M.; Marinelli, B.; Grassman, J. A.; Bertazzi, P. A.; Landi, M. T.

In: Giornale Italiano di Medicina del Lavoro ed Ergonomia, Vol. 26, No. 4 SUPPL., 26.11.2004, p. 22-23.

Research output: Contribution to journalArticle

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AU - Baccarelli, A.

AU - Pesatori, A.

AU - Consonni, D.

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AU - Bonzini, M.

AU - Marinelli, B.

AU - Grassman, J. A.

AU - Bertazzi, P. A.

AU - Landi, M. T.

PY - 2004/11/26

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