Molecular approaches to identify exposure and risk to specific environmental pollutants

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

Ecotoxicology and environmental epidemiology require an intimate understanding of the relationship between exposure of a population to a pollutant and the subsequent biological effects. This article summarizes two relatively new and powerful techniques to examine both exposure and response to environmental pollutants which build upon an increased understanding of how particular classes of chemicals elicit toxicity at the molecular level. The genetic reporter assay can be used to examine the exposure and potential toxicity of environmental samples. Quantitative polymerase chain reaction (PCR) is an exquisitely sensitive and adaptable procedure to examine early events, i.e. biomarkers, that might be indicative of exposure and/or sensitivity to a chemical insult. Taken together, these assays are important new tools in assessing the exposure and risk of human and wildlife populations to such important pollutants as dioxins, PCBs, oestrogenic and anti-oestrogenic compounds, phthalate esters, DDT metabolites and heavy metals.

Original languageEnglish (US)
Pages (from-to)93-105
Number of pages13
JournalBiomarkers
Volume4
Issue number2
StatePublished - Mar 1 1999

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Environmental Pollutants
Toxicity
Assays
Ecotoxicology
Epidemiology
Dioxins
DDT
Polymerase chain reaction
Polychlorinated Biphenyls
Biomarkers
Metabolites
Heavy Metals
Population
Esters
Polymerase Chain Reaction
phthalic acid

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Clinical Biochemistry
  • Health, Toxicology and Mutagenesis

Cite this

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title = "Molecular approaches to identify exposure and risk to specific environmental pollutants",
abstract = "Ecotoxicology and environmental epidemiology require an intimate understanding of the relationship between exposure of a population to a pollutant and the subsequent biological effects. This article summarizes two relatively new and powerful techniques to examine both exposure and response to environmental pollutants which build upon an increased understanding of how particular classes of chemicals elicit toxicity at the molecular level. The genetic reporter assay can be used to examine the exposure and potential toxicity of environmental samples. Quantitative polymerase chain reaction (PCR) is an exquisitely sensitive and adaptable procedure to examine early events, i.e. biomarkers, that might be indicative of exposure and/or sensitivity to a chemical insult. Taken together, these assays are important new tools in assessing the exposure and risk of human and wildlife populations to such important pollutants as dioxins, PCBs, oestrogenic and anti-oestrogenic compounds, phthalate esters, DDT metabolites and heavy metals.",
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Molecular approaches to identify exposure and risk to specific environmental pollutants. / Vanden Heuvel, John Patrick; Davis, John W.

In: Biomarkers, Vol. 4, No. 2, 01.03.1999, p. 93-105.

Research output: Contribution to journalReview article

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AB - Ecotoxicology and environmental epidemiology require an intimate understanding of the relationship between exposure of a population to a pollutant and the subsequent biological effects. This article summarizes two relatively new and powerful techniques to examine both exposure and response to environmental pollutants which build upon an increased understanding of how particular classes of chemicals elicit toxicity at the molecular level. The genetic reporter assay can be used to examine the exposure and potential toxicity of environmental samples. Quantitative polymerase chain reaction (PCR) is an exquisitely sensitive and adaptable procedure to examine early events, i.e. biomarkers, that might be indicative of exposure and/or sensitivity to a chemical insult. Taken together, these assays are important new tools in assessing the exposure and risk of human and wildlife populations to such important pollutants as dioxins, PCBs, oestrogenic and anti-oestrogenic compounds, phthalate esters, DDT metabolites and heavy metals.

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