In summary, information obtained from single gene transfer into EBV-negative cell lines is consistent with molecular genetic analysis of in vitro transformation by the whole virus in emphasizing the role for EBNA2 and LMP-1 in cell growth transformation. In addition, the functions of the latent infection proteins in tissue culture cells is consistent with the pathology of the EBV-associated lesions. The repertoire of viral proteins displayed in vivo varies with the different tissues infected and the differentiation state of infected cells, and is likely to reflect, in part, the activity of the latent infection promoters in these cells. Recent methods for obtaining specific virus mutants will enable more complete characterization of the EBV latent infection proteins and their roles in EBV-induced immortalization and pathogenesis .
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