Molecular cloning and developmental expression of a zebrafish axonal glycoprotein similar to TAG-1

James T. Warren, Anand Chandrasekhar, John P. Kanki, Radha Rangarajan, Andrew J. Furley, John Y. Kuwada

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

TAG-1 is a mammalian cell adhesion molecule of the immunoglobulin superfamily that is expressed transiently by a subset of neurons and serves as a fertile substrate for neurite outgrowth in vitro (Furley, A.H., Morton, S.B., Manalo, D., Karagogeos, S., Dodd, H., Jessell, T.M., 1990 The axonal glycoprotein TAG-1 is an immunoglobulin superfamily member with neurite outgrowth promoting activity. Cell 61, 157-170). In order to examine the in vivo function of this molecule, we have cloned a zebrafish tag1-like cDNA and analyzed its expression patterns. tag1 is expressed transiently by specific subsets of neurons when they are projecting their axons or when they are migrating. The specific and dynamic pattern of expression of zebrafish tag1 is consistent with its proposed role in axon guidance and cell migration.

Original languageEnglish (US)
Pages (from-to)197-201
Number of pages5
JournalMechanisms of Development
Volume80
Issue number2
DOIs
StatePublished - Feb 1 1999

All Science Journal Classification (ASJC) codes

  • Embryology
  • Developmental Biology

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