Molecular cloning of a testis-specific gene from mouse chromosome 17

M. Kasahara, F. Figueroa, J. Klein

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Abstract

A testis-specific gene located distal to Qa-2 was cloned from mouse chromosome 17. Although we still do not have any formal proof, several lines of evidence suggest that this gene might encode a testis-specific Pgk-2 isozyme. First, the tissue distribution of this gene is identical with that of Pgk-2. Second, the size of the 1-1-1 testicular transcript roughly coincides with that of the human X-linked PGK1. Third, 1-1-1 maps, like Pgk-2, distal to Qa-2. And fourth, in a preliminary survey of classical inbred strains, 1-1-1 detects restriction fragment length polymorphism concordant with the known allelic distribution of Pgk-2. DNA sequence information will provide a definite identification of this gene.

Original languageEnglish (US)
Pages (from-to)815-816
Number of pages2
JournalTransplantation proceedings
Volume19
Issue number1 I
StatePublished - Jan 1 1987

All Science Journal Classification (ASJC) codes

  • Surgery
  • Transplantation

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    Kasahara, M., Figueroa, F., & Klein, J. (1987). Molecular cloning of a testis-specific gene from mouse chromosome 17. Transplantation proceedings, 19(1 I), 815-816.