Molecular encryption and reconfiguration for remodeling of dynamic hydrogels

Shihui Li, Erin R. Gaddes, Niancao Chen, Yong Wang

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Dynamic materials have been widely studied for regulation of cell adhesion that is important to a variety of biological and biomedical applications. These materials can undergo changes mainly through one of the two mechanisms: ligand release in response to chemical, physical, or biological stimuli, and ligand burial in response to mechanical stretching or the change of electrical potential. This study demonstrates an encrypted ligand and a new hydrogel that are capable of inducing and inhibiting cell adhesion, which is controlled by molecular reconfiguration. The ligand initially exhibits an inert state; it can be reconfigured into active and inert states by using unblocking and recovering molecules in physiological conditions. Since molecular reconfiguration does not require the release of the ligand from the hydrogels, inhibiting and inducing cell adhesion on the hydrogels can be repeated for multiple cycles.

Original languageEnglish (US)
Pages (from-to)5957-5961
Number of pages5
JournalAngewandte Chemie - International Edition
Volume54
Issue number20
DOIs
StatePublished - May 11 2015

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

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