Molecular mechanisms of erythropoietin signaling

Joseph Y. Cheung, Barbara Miller

Research output: Contribution to journalArticlepeer-review

57 Scopus citations

Abstract

Erythropoietin is an obligatory growth factor for red blood cell production. The receptor for erythropoietin contains a single membrane-spanning domain with no intrinsic tyrosine kinase motifs. On binding to erythropoietin, the receptor dimerizes and activates multiple intracellular signaling molecules, including but not limited to JAK2, STAT5, PI 3-kinase, IRS-2, RAS, and Ca2+ channels. This review focuses on cytoplasmic signaling cascades involved in erythropoietin action.

Original languageEnglish (US)
Pages (from-to)215-222
Number of pages8
JournalNephron
Volume87
Issue number3
DOIs
StatePublished - 2001

All Science Journal Classification (ASJC) codes

  • Physiology
  • Nephrology
  • Physiology (medical)
  • Urology

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