Molecular mechanisms of erythropoietin signaling

Joseph Y. Cheung, Barbara Miller

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Erythropoietin is an obligatory growth factor for red blood cell production. The receptor for erythropoietin contains a single membrane-spanning domain with no intrinsic tyrosine kinase motifs. On binding to erythropoietin, the receptor dimerizes and activates multiple intracellular signaling molecules, including but not limited to JAK2, STAT5, PI 3-kinase, IRS-2, RAS, and Ca2+ channels. This review focuses on cytoplasmic signaling cascades involved in erythropoietin action.

Original languageEnglish (US)
Pages (from-to)215-222
Number of pages8
JournalNephron
Volume87
Issue number3
DOIs
StatePublished - Apr 17 2001

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Erythropoietin Receptors
Erythropoietin
Phosphatidylinositol 3-Kinases
Protein-Tyrosine Kinases
Intercellular Signaling Peptides and Proteins
Erythrocytes
Membranes

All Science Journal Classification (ASJC) codes

  • Nephrology

Cite this

Cheung, Joseph Y. ; Miller, Barbara. / Molecular mechanisms of erythropoietin signaling. In: Nephron. 2001 ; Vol. 87, No. 3. pp. 215-222.
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Molecular mechanisms of erythropoietin signaling. / Cheung, Joseph Y.; Miller, Barbara.

In: Nephron, Vol. 87, No. 3, 17.04.2001, p. 215-222.

Research output: Contribution to journalArticle

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