Molecular modeling tools and approaches for CFTR and cystic fibrosis.

Adrian W.R. Serohijos, Patrick H. Thibodeau, Nikolay V. Dokholyan

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Cystic fibrosis is a multi-faceted disease resulting from the dysfunction of the CFTR channel. Understanding the structural basis of channel function and the structural origin of the defect is imperative in the development of therapeutic strategies. Here, we describe molecular modeling tools that, in conjunction with complementary experimental tools, lead to significant findings on CFTR channel function and on the effect of the pathogenic mutant F508del.

Original languageEnglish (US)
Pages (from-to)347-363
Number of pages17
JournalMethods in molecular biology (Clifton, N.J.)
Volume741
DOIs
StatePublished - Sep 7 2011

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Cystic Fibrosis
Therapeutics

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics

Cite this

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Molecular modeling tools and approaches for CFTR and cystic fibrosis. / Serohijos, Adrian W.R.; Thibodeau, Patrick H.; Dokholyan, Nikolay V.

In: Methods in molecular biology (Clifton, N.J.), Vol. 741, 07.09.2011, p. 347-363.

Research output: Contribution to journalArticle

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