Molecular regulation of lactation: The complex and requisite roles for zinc

Sooyeon Lee, Shannon L. Kelleher

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Lactation provides many health benefits to the nursing infant and breastfeeding mother. In order to successfully breastfeed, the mammary gland must expand and differentiate to activate numerous processes that regulate milk production and secretion. This involves a complex series of molecular, biochemical and cellular events driven largely by lactogenic hormones. Recent advances implicate zinc as a critical modulator of mammary gland function. Here, we provide an overview of our current understanding of the role and regulation of zinc in promoting proliferation, differentiation and secretion in the mammary gland during lactation, and highlight critical gaps in knowledge.

Original languageEnglish (US)
Pages (from-to)86-92
Number of pages7
JournalArchives of Biochemistry and Biophysics
Volume611
DOIs
StatePublished - Dec 1 2016

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology

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