Molecular structure and transformation of the glucose dehydrogenase gene in Drosophila melanogaster.

R. Whetten, E. Organ, P. Krasney, Diana Lynn Cox-foster, Douglas R. Cavener

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

We have precisely mapped and sequenced the three 5' exons of the Drosophila melanogaster Gld gene and have identified the start sites for transcription and translation. The first exon is composed of 335 nucleotides and does not contain any putative translation start codons. The second exon is separated from the first exon by 8 kb and contains the Gld translation start codon. The inferred amino acid sequence of the amino terminus contains two unusual features: three tandem repeats of serine-alanine, and a relatively high density of cysteine residues. P element-mediated transformation experiments demonstrated that a 17.5-kb genomic fragment contains the functional and regulatory components of the Gld gene.

Original languageEnglish (US)
Pages (from-to)475-484
Number of pages10
JournalGenetics
Volume120
Issue number2
StatePublished - Jan 1 1988

All Science Journal Classification (ASJC) codes

  • Genetics

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