Molecular structure of the gene products of the human HLA system: isolation and characterization of HLA-A, -B, -C, and Ia antigens

M. J. Crumpton, D. Snary, F. S. Walsh, C. J. Barnstable, P. N. Goodfellow, E. A. Jones, W. F. Bodmer

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

The major histocompatibility region of man (HLA) codes for two groups of polymorphic cell surface membrane antigens. One group comprises the products of the A, B and C loci. The second group represents the Ia (immune-associated) antigens, some of which show a close association with the D locus. The strategy employed for the isolation of these antigens and the establishment of their molecular structures is reviewed. The A, B and C antigens are composed of a 43 000 molecular mass glycosylated polypeptide which carries the polymorphic specificities and which is non-covalently linked to a non-glycosylated polypeptide of molecular mass 12 000, namely β2-microglobulin. Structural analyses indicate that the A and B antigens have arisen by gene duplication and that the C gene(s) probably arose from the A gene(s). The Ia antigens do not contain β2-microglobulin but comprise two non-covalently linked glycosylated polypeptides of molecular masses 33 000 and 28 000. Only the 33 000 molecular mass chain is apparently a product of the HLA region.

Original languageEnglish (US)
Pages (from-to)159-175
Number of pages17
JournalUnknown Journal
Volume202
Issue number1146
DOIs
StatePublished - Jan 1 1978

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Environmental Science(all)
  • Agricultural and Biological Sciences(all)

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