We determined the association between daily ambulatory activity and markers of inflammation and oxidative stress in patients with peripheral artery disease (PAD) and claudication. Patients with PAD (n = 134) limited by claudication were studied. Patients took 3275 ± 1743 daily strides for 273 ± 112 minutes each day, and their average daily cadence was 11.7 ± 2.7 strides/min. High-sensitivity C-reactive protein was significantly and negatively associated with the total number of daily strides (P <.001), total daily ambulatory time (P <.01), peak activity index (P <.01), daily average cadence (P <.05), and the maximum cadences for 60 minutes (P <.05), 30 minutes (P <.05), 20 minutes (P <.05), and 5 minutes (P <.01). Oxidized low-density lipoprotein and soluble vascular cell adhesion molecule 1 were not significantly associated with any of the ambulatory measures (P >.05). We conclude that higher levels of community-based, daily ambulatory activity are associated with lower levels of inflammation but are not associated with markers of oxidative stress.
All Science Journal Classification (ASJC) codes
- Cardiology and Cardiovascular Medicine