Monochromatic Near-infrared to near-infrared upconversion nanoparticles for high-contrast fluorescence imaging

Jiayin Zhang, Hua Zhao, Xitian Zhang, Xuanzhang Wang, Hong Gao, Zhiguo Zhang, Wenwu Cao

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

To develop a fluorescent bioprobe for high-contrast deep tissue fluorescence imaging, monochromatic 800 nm upconversion emissions based on NaYF4: Yb3+, Tm3+ upconversion nanoparticles are investigated. The ratio of I800 to I470, which is used to describe the monochromaticity, showing exponential growth with the increase of Tm3+ doping concentration in NaYF4: Yb3+, Tm3+ nanoparticles, can reach as high as 757 at 4% Tm3+. At such a doping level, the absolute quantum efficiency can reach 3.9 × 10-3 as measured by a calibrated integrating sphere, which is sufficient for fluorescence imaging. High-contrast fluorescence phantom imaging was obtained by adjusting monochromaticity of 800 nm upconversion emission under the excitation of a 980 nm diode laser.

Original languageEnglish (US)
Pages (from-to)2820-2825
Number of pages6
JournalJournal of Physical Chemistry C
Volume118
Issue number5
DOIs
StatePublished - Feb 6 2014

Fingerprint

Fluorescence
Nanoparticles
Infrared radiation
Imaging techniques
fluorescence
nanoparticles
Doping (additives)
Quantum efficiency
Semiconductor lasers
quantum efficiency
adjusting
semiconductor lasers
Tissue
excitation

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Energy(all)
  • Physical and Theoretical Chemistry
  • Surfaces, Coatings and Films

Cite this

Zhang, Jiayin ; Zhao, Hua ; Zhang, Xitian ; Wang, Xuanzhang ; Gao, Hong ; Zhang, Zhiguo ; Cao, Wenwu. / Monochromatic Near-infrared to near-infrared upconversion nanoparticles for high-contrast fluorescence imaging. In: Journal of Physical Chemistry C. 2014 ; Vol. 118, No. 5. pp. 2820-2825.
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abstract = "To develop a fluorescent bioprobe for high-contrast deep tissue fluorescence imaging, monochromatic 800 nm upconversion emissions based on NaYF4: Yb3+, Tm3+ upconversion nanoparticles are investigated. The ratio of I800 to I470, which is used to describe the monochromaticity, showing exponential growth with the increase of Tm3+ doping concentration in NaYF4: Yb3+, Tm3+ nanoparticles, can reach as high as 757 at 4{\%} Tm3+. At such a doping level, the absolute quantum efficiency can reach 3.9 × 10-3 as measured by a calibrated integrating sphere, which is sufficient for fluorescence imaging. High-contrast fluorescence phantom imaging was obtained by adjusting monochromaticity of 800 nm upconversion emission under the excitation of a 980 nm diode laser.",
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Monochromatic Near-infrared to near-infrared upconversion nanoparticles for high-contrast fluorescence imaging. / Zhang, Jiayin; Zhao, Hua; Zhang, Xitian; Wang, Xuanzhang; Gao, Hong; Zhang, Zhiguo; Cao, Wenwu.

In: Journal of Physical Chemistry C, Vol. 118, No. 5, 06.02.2014, p. 2820-2825.

Research output: Contribution to journalArticle

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T1 - Monochromatic Near-infrared to near-infrared upconversion nanoparticles for high-contrast fluorescence imaging

AU - Zhang, Jiayin

AU - Zhao, Hua

AU - Zhang, Xitian

AU - Wang, Xuanzhang

AU - Gao, Hong

AU - Zhang, Zhiguo

AU - Cao, Wenwu

PY - 2014/2/6

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AB - To develop a fluorescent bioprobe for high-contrast deep tissue fluorescence imaging, monochromatic 800 nm upconversion emissions based on NaYF4: Yb3+, Tm3+ upconversion nanoparticles are investigated. The ratio of I800 to I470, which is used to describe the monochromaticity, showing exponential growth with the increase of Tm3+ doping concentration in NaYF4: Yb3+, Tm3+ nanoparticles, can reach as high as 757 at 4% Tm3+. At such a doping level, the absolute quantum efficiency can reach 3.9 × 10-3 as measured by a calibrated integrating sphere, which is sufficient for fluorescence imaging. High-contrast fluorescence phantom imaging was obtained by adjusting monochromaticity of 800 nm upconversion emission under the excitation of a 980 nm diode laser.

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