Monoclonal antibody to Thy-1 enhances regeneration of processes by rat retinal ganglion cells in culture

Dana Leifer, Stuart A. Lipton, Colin J. Barnstable, Richard H. Masland

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Abstract

Ganglion cells were dissociated from postnatal rat retinas, identified by specific fluorescent labels, and maintained in culture on a variety of substrates. Regeneration of processes by retinal ganglion cells was enhanced when the cells were plated on glass coated with a monoclonal antibody against the Thy-1 determinant. Plain glass and glass coated with polylysine, collagen, fibronectin, or other monoclonal antibodies supported the growth of neural processes, but were less effective than antibody to Thy-1.

Original languageEnglish (US)
Pages (from-to)303-306
Number of pages4
JournalScience
Volume224
Issue number4646
DOIs
Publication statusPublished - Jan 1 1984

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All Science Journal Classification (ASJC) codes

  • General

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