Monoclonal antibody to Thy-1 enhances regeneration of processes by rat retinal ganglion cells in culture

Dana Leifer, Stuart A. Lipton, Colin Barnstable, Richard H. Masland

Research output: Contribution to journalArticle

156 Citations (Scopus)

Abstract

Ganglion cells were dissociated from postnatal rat retinas, identified by specific fluorescent labels, and maintained in culture on a variety of substrates. Regeneration of processes by retinal ganglion cells was enhanced when the cells were plated on glass coated with a monoclonal antibody against the Thy-1 determinant. Plain glass and glass coated with polylysine, collagen, fibronectin, or other monoclonal antibodies supported the growth of neural processes, but were less effective than antibody to Thy-1.

Original languageEnglish (US)
Pages (from-to)303-306
Number of pages4
JournalScience
Volume224
Issue number4646
DOIs
StatePublished - Jan 1 1984

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Retinal Ganglion Cells
Glass
Regeneration
Cell Culture Techniques
Monoclonal Antibodies
Polylysine
Fibronectins
Ganglia
Retina
Collagen
Antibodies
Growth

All Science Journal Classification (ASJC) codes

  • General

Cite this

Leifer, Dana ; Lipton, Stuart A. ; Barnstable, Colin ; Masland, Richard H. / Monoclonal antibody to Thy-1 enhances regeneration of processes by rat retinal ganglion cells in culture. In: Science. 1984 ; Vol. 224, No. 4646. pp. 303-306.
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Monoclonal antibody to Thy-1 enhances regeneration of processes by rat retinal ganglion cells in culture. / Leifer, Dana; Lipton, Stuart A.; Barnstable, Colin; Masland, Richard H.

In: Science, Vol. 224, No. 4646, 01.01.1984, p. 303-306.

Research output: Contribution to journalArticle

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