Abstract
Ganglion cells were dissociated from postnatal rat retinas, identified by specific fluorescent labels, and maintained in culture on a variety of substrates. Regeneration of processes by retinal ganglion cells was enhanced when the cells were plated on glass coated with a monoclonal antibody against the Thy-1 determinant. Plain glass and glass coated with polylysine, collagen, fibronectin, or other monoclonal antibodies supported the growth of neural processes, but were less effective than antibody to Thy-1.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 303-306 |
| Number of pages | 4 |
| Journal | Science |
| Volume | 224 |
| Issue number | 4646 |
| DOIs | |
| State | Published - Jan 1 1984 |
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All Science Journal Classification (ASJC) codes
- General
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Monoclonal antibody to Thy-1 enhances regeneration of processes by rat retinal ganglion cells in culture. / Leifer, Dana; Lipton, Stuart A.; Barnstable, Colin; Masland, Richard H.
In: Science, Vol. 224, No. 4646, 01.01.1984, p. 303-306.Research output: Contribution to journal › Article
TY - JOUR
T1 - Monoclonal antibody to Thy-1 enhances regeneration of processes by rat retinal ganglion cells in culture
AU - Leifer, Dana
AU - Lipton, Stuart A.
AU - Barnstable, Colin
AU - Masland, Richard H.
PY - 1984/1/1
Y1 - 1984/1/1
N2 - Ganglion cells were dissociated from postnatal rat retinas, identified by specific fluorescent labels, and maintained in culture on a variety of substrates. Regeneration of processes by retinal ganglion cells was enhanced when the cells were plated on glass coated with a monoclonal antibody against the Thy-1 determinant. Plain glass and glass coated with polylysine, collagen, fibronectin, or other monoclonal antibodies supported the growth of neural processes, but were less effective than antibody to Thy-1.
AB - Ganglion cells were dissociated from postnatal rat retinas, identified by specific fluorescent labels, and maintained in culture on a variety of substrates. Regeneration of processes by retinal ganglion cells was enhanced when the cells were plated on glass coated with a monoclonal antibody against the Thy-1 determinant. Plain glass and glass coated with polylysine, collagen, fibronectin, or other monoclonal antibodies supported the growth of neural processes, but were less effective than antibody to Thy-1.
UR - http://www.scopus.com/inward/record.url?scp=0021365377&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021365377&partnerID=8YFLogxK
U2 - 10.1126/science.6143400
DO - 10.1126/science.6143400
M3 - Article
C2 - 6143400
AN - SCOPUS:0021365377
VL - 224
SP - 303
EP - 306
JO - Science
JF - Science
SN - 0036-8075
IS - 4646
ER -