TY - JOUR
T1 - Monoclonal antibody to Thy-1 enhances regeneration of processes by rat retinal ganglion cells in culture
AU - Leifer, Dana
AU - Lipton, Stuart A.
AU - Barnstable, Colin J.
AU - Masland, Richard H.
PY - 1984
Y1 - 1984
N2 - Ganglion cells were dissociated from postnatal rat retinas, identified by specific fluorescent labels, and maintained in culture on a variety of substrates. Regeneration of processes by retinal ganglion cells was enhanced when the cells were plated on glass coated with a monoclonal antibody against the Thy-1 determinant. Plain glass and glass coated with polylysine, collagen, fibronectin, or other monoclonal antibodies supported the growth of neural processes, but were less effective than antibody to Thy-1.
AB - Ganglion cells were dissociated from postnatal rat retinas, identified by specific fluorescent labels, and maintained in culture on a variety of substrates. Regeneration of processes by retinal ganglion cells was enhanced when the cells were plated on glass coated with a monoclonal antibody against the Thy-1 determinant. Plain glass and glass coated with polylysine, collagen, fibronectin, or other monoclonal antibodies supported the growth of neural processes, but were less effective than antibody to Thy-1.
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U2 - 10.1126/science.6143400
DO - 10.1126/science.6143400
M3 - Article
C2 - 6143400
AN - SCOPUS:0021365377
VL - 224
SP - 303
EP - 306
JO - Science
JF - Science
SN - 0036-8075
IS - 4646
ER -