Monte Carlo simulation of heterotypic cell aggregation in nonlinear shear flow

Jiakou Wang, Margaret J. Slattery, Meghan Henty Hoskins, Shile Liang, Cheng Dong, Qiang Du

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

In this paper, we develop a population balance model for cell aggregation and adhesion process in a nonuniform shear flow. Some Monte Carlo simulation results based on the model are presented for the heterotypic cell-cell collision and adhesion to a substrate under dynamic shear forces. In particular, we focus on leukocyte (PMN)-melanoma cell emboli formation and subsequent tethering to the vascular endothelium (EC) as a result of cell-cell aggregation. The simulation results are compared with the results of experimental measurement. Discussions are made on how we could further improve the accuracy of the population balance type modelling.

Original languageEnglish (US)
Pages (from-to)683-696
Number of pages14
JournalMathematical Biosciences and Engineering
Volume3
Issue number4
DOIs
StatePublished - Oct 2006

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All Science Journal Classification (ASJC) codes

  • Modeling and Simulation
  • Agricultural and Biological Sciences(all)
  • Computational Mathematics
  • Applied Mathematics

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