Mood response to deep brain stimulation of the subthalamic nucleus in Parkinson's disease

Meghan C. Campbell, Kevin J. Black, Patrick M. Weaver, Heather M. Lugar, Tom O. Videen, Samer D. Tabbal, Morvarid Karimi, Joel S. Perlmutter, Tamara Hershey

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

Deep brain stimulation of the sub thalamic nucleus (STN DBS) in Parkinson's disease (PD) improves motor functioning but has variable effects on mood. Little is known about the relationship between electrode contact location and mood response. The authors identified the anatomical location of electrode contacts and measured mood response to stimulation with the Visual Analog Scale in 24 STN DBS PD patients. Participants reported greater positive mood and decreased anxiety and apathy with bilateral and unilateral stimulation. Left DBS improved mood more than right DBS. Right DBS-induced increase in positive mood was related to more medial and dorsal contact locations. These results highlight the functional heterogeneity of the STN.

Original languageEnglish (US)
Pages (from-to)28-36
Number of pages9
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Volume24
Issue number1
DOIs
StatePublished - 2012

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Psychiatry and Mental health

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