Morphine and brain growth retardation in the rat

Research output: Contribution to journalArticle

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Abstract

Fetal and infant rats were maternally exposed to morphine sulfate during gestation and lactation. Drug was administered twice daily by i.p. injection, with dosages gradually increased from 10 mg/kg/injection to a maintenance level of 40 mg/kg/injection. Offspring observed during the preweaning period had a reduction in body, brain and cerebellar weights, as well as in brain length and cerebral and cerebellar widths. Deficits persisted in young rats observed 5 1/2 weeks after cessation of drug exposure and in animals continuing to receive twice daily i.p. injections of 20 mg/kg/injection. These results indicate that maternal morphine treatment retards the growth of young rats and impairs brain development.

Original languageEnglish (US)
Pages (from-to)276-282
Number of pages7
JournalPharmacology
Volume15
Issue number3
DOIs
StatePublished - Jan 1 1977

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Morphine
Injections
Brain
Growth
Lactation
Pharmaceutical Preparations
Maintenance
Mothers
Weights and Measures
Pregnancy
Therapeutics

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

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Morphine and brain growth retardation in the rat. / Zagon, I. S.; McLaughlin, P. J.

In: Pharmacology, Vol. 15, No. 3, 01.01.1977, p. 276-282.

Research output: Contribution to journalArticle

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