Morphine-based secondary reinforcement: Effects of different doses of naloxone

Richard Marcus, Gilbert Carnathan, Roger Meyer, Joseph Cochin

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The effects of different doses of naloxone on morphine-based secondary reinforcement were studied in rats. On the first day a neutral stimulus (buzzer) was repeatedly paired with intravenous morphine infusions. Drug treatments consisted of Low, Medium, or High Naloxone doses, or No Naloxone. The next day the ability of the buzzer and saline infusion to support lever pressing was tested. High Naloxone blocked, and Low Naloxone partially blocked this morphine-based secondary reinforcement. Subjects in the Medium Naloxone group demonstrated an apparent avoidance of the lever, suggesting that the morphine infusions were aversive at this dosage level of naloxone. The secondary reinforcement tests reliably predicted behavior on a subsequent test for acquisition of morphine-seeking behavior.

Original languageEnglish (US)
Pages (from-to)247-250
Number of pages4
JournalPsychopharmacology
Volume48
Issue number3
DOIs
StatePublished - Jan 1 1976

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Naloxone
Morphine
Aptitude
Reinforcement (Psychology)
Intravenous Infusions
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

Marcus, Richard ; Carnathan, Gilbert ; Meyer, Roger ; Cochin, Joseph. / Morphine-based secondary reinforcement : Effects of different doses of naloxone. In: Psychopharmacology. 1976 ; Vol. 48, No. 3. pp. 247-250.
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Marcus, R, Carnathan, G, Meyer, R & Cochin, J 1976, 'Morphine-based secondary reinforcement: Effects of different doses of naloxone', Psychopharmacology, vol. 48, no. 3, pp. 247-250. https://doi.org/10.1007/BF00496856

Morphine-based secondary reinforcement : Effects of different doses of naloxone. / Marcus, Richard; Carnathan, Gilbert; Meyer, Roger; Cochin, Joseph.

In: Psychopharmacology, Vol. 48, No. 3, 01.01.1976, p. 247-250.

Research output: Contribution to journalArticle

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