Morphine-induced suppression of saccharin intake is correlated with elevated corticosterone levels

Felipe Gomez, Nicole A. Leo, Patricia S. Grigson

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

Rats suppress intake of a saccharin conditioned stimulus (CS) when paired with a drug of abuse. This phenomenon, however, is not uniform across all subjects and is greater following exposure to stress and in animals that more readily self-administer drugs of abuse. The present study was designed to examine these individual differences in intake suppression following seven saccharin-morphine pairings. Plasma corticosterone also was evaluated both before and after conditioning in order to determine whether the magnitude of CS suppression is, or is not, related to circulating corticosterone levels. The findings indicated that, while all rats were exposed to the same number of saccharin-morphine pairings, only half of these animals actually suppressed intake of the saccharin CS. Moreover, the results showed that greater suppression of CS intake was associated with higher corticosterone levels at test (r=-0.84, P<0.0001). Taken together, the results demonstrate that individual differences affect not only the reduction in CS intake following taste-drug pairings, but also the associated cue-induced elevation in circulating corticosterone. Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)52-58
Number of pages7
JournalBrain research
Volume863
Issue number1-2
DOIs
StatePublished - Apr 28 2000

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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