Mortality and biomarkers of aging in heterogeneous stock (HS) mice

Debra Ann Heller, Frank Martin Ahern, J. Tobias Stout, Gerald E. McClearn

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

A longitudinal study was undertaken to evaluate the relationships among a battery of aging biomarkers and subsequent survival time in 319 genetically heterogenous stock (HS) mice. The biomarker variables chosen were selected from the broad domains of behavior, homeostatic physiology, oxidative defense, and immune function; biomarkers were measured at 45, 90, 360, 630, and 900 days of age. Sex differences were found in the survivor and mortality functions, with a mortality rate crossover occurring at about 525 days and a survival curve crossover at about 750 days of age. Females experienced lower initial mortality but had more sharply increasing mortality with age than did males. Survival analysis using Gompertz parametric models with biomarkers as time-varying covariates yielded significant biomarkers from each domain. Following backward elimination procedures, the final set of independent mortality predictors included headpokes in the File activity apparatus, maximum cord drop time, weight, hematocrit, urine concentration, natural killer cell activity, and concanavalin A response.

Original languageEnglish (US)
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume53
Issue number3
DOIs
StatePublished - Jan 1 1998

Fingerprint

Biomarkers
Mortality
Survival
Survival Analysis
Concanavalin A
Hematocrit
Sex Characteristics
Natural Killer Cells
Longitudinal Studies
Survivors
Urine
Weights and Measures

All Science Journal Classification (ASJC) codes

  • Aging
  • Geriatrics and Gerontology

Cite this

Heller, Debra Ann ; Ahern, Frank Martin ; Stout, J. Tobias ; McClearn, Gerald E. / Mortality and biomarkers of aging in heterogeneous stock (HS) mice. In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 1998 ; Vol. 53, No. 3.
@article{854918937f3745feaad9b688d6048785,
title = "Mortality and biomarkers of aging in heterogeneous stock (HS) mice",
abstract = "A longitudinal study was undertaken to evaluate the relationships among a battery of aging biomarkers and subsequent survival time in 319 genetically heterogenous stock (HS) mice. The biomarker variables chosen were selected from the broad domains of behavior, homeostatic physiology, oxidative defense, and immune function; biomarkers were measured at 45, 90, 360, 630, and 900 days of age. Sex differences were found in the survivor and mortality functions, with a mortality rate crossover occurring at about 525 days and a survival curve crossover at about 750 days of age. Females experienced lower initial mortality but had more sharply increasing mortality with age than did males. Survival analysis using Gompertz parametric models with biomarkers as time-varying covariates yielded significant biomarkers from each domain. Following backward elimination procedures, the final set of independent mortality predictors included headpokes in the File activity apparatus, maximum cord drop time, weight, hematocrit, urine concentration, natural killer cell activity, and concanavalin A response.",
author = "Heller, {Debra Ann} and Ahern, {Frank Martin} and Stout, {J. Tobias} and McClearn, {Gerald E.}",
year = "1998",
month = "1",
day = "1",
doi = "10.1093/gerona/53A.3.B217",
language = "English (US)",
volume = "53",
journal = "Journals of Gerontology - Series A Biological Sciences and Medical Sciences",
issn = "1079-5006",
publisher = "Oxford University Press",
number = "3",

}

Mortality and biomarkers of aging in heterogeneous stock (HS) mice. / Heller, Debra Ann; Ahern, Frank Martin; Stout, J. Tobias; McClearn, Gerald E.

In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 53, No. 3, 01.01.1998.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Mortality and biomarkers of aging in heterogeneous stock (HS) mice

AU - Heller, Debra Ann

AU - Ahern, Frank Martin

AU - Stout, J. Tobias

AU - McClearn, Gerald E.

PY - 1998/1/1

Y1 - 1998/1/1

N2 - A longitudinal study was undertaken to evaluate the relationships among a battery of aging biomarkers and subsequent survival time in 319 genetically heterogenous stock (HS) mice. The biomarker variables chosen were selected from the broad domains of behavior, homeostatic physiology, oxidative defense, and immune function; biomarkers were measured at 45, 90, 360, 630, and 900 days of age. Sex differences were found in the survivor and mortality functions, with a mortality rate crossover occurring at about 525 days and a survival curve crossover at about 750 days of age. Females experienced lower initial mortality but had more sharply increasing mortality with age than did males. Survival analysis using Gompertz parametric models with biomarkers as time-varying covariates yielded significant biomarkers from each domain. Following backward elimination procedures, the final set of independent mortality predictors included headpokes in the File activity apparatus, maximum cord drop time, weight, hematocrit, urine concentration, natural killer cell activity, and concanavalin A response.

AB - A longitudinal study was undertaken to evaluate the relationships among a battery of aging biomarkers and subsequent survival time in 319 genetically heterogenous stock (HS) mice. The biomarker variables chosen were selected from the broad domains of behavior, homeostatic physiology, oxidative defense, and immune function; biomarkers were measured at 45, 90, 360, 630, and 900 days of age. Sex differences were found in the survivor and mortality functions, with a mortality rate crossover occurring at about 525 days and a survival curve crossover at about 750 days of age. Females experienced lower initial mortality but had more sharply increasing mortality with age than did males. Survival analysis using Gompertz parametric models with biomarkers as time-varying covariates yielded significant biomarkers from each domain. Following backward elimination procedures, the final set of independent mortality predictors included headpokes in the File activity apparatus, maximum cord drop time, weight, hematocrit, urine concentration, natural killer cell activity, and concanavalin A response.

UR - http://www.scopus.com/inward/record.url?scp=0031749354&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031749354&partnerID=8YFLogxK

U2 - 10.1093/gerona/53A.3.B217

DO - 10.1093/gerona/53A.3.B217

M3 - Article

VL - 53

JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences

JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences

SN - 1079-5006

IS - 3

ER -