Mother-infant interactions and infant development are altered by maternal iron deficiency anemia

Eva M. Perez, Michael K. Hendricks, John L. Beard, Laura E. Murray-Kolb, Astrid Berg, Mark Tomlinson, James Irlam, Washiefa Isaacs, T. Njengele, Alan Sive, Lynne Vernon-Feagans

Research output: Contribution to journalArticle

116 Citations (Scopus)

Abstract

The aim of this study was to determine whether iron deficiency anemia (IDA) in young South African mothers alters mother-infant interactions and the infant's development. The study was a prospective, randomized, controlled intervention trial with 3 groups of mothers: nonanemic controls and anemic mothers administered either placebo (25 mg ascorbic acid and 10 μg folate) or daily iron treatment (125 mg FeSO4 plus ascorbate and folate). Mothers of full-term, normal birth weight infants (n = 81) were followed from 10 wk to 9 mo postpartum. Maternal iron status, socioeconomic level, mother-infant interaction [Parent/Caregiver Involvement Scale (PCIS scale)], and infant development (Griffiths scale) were assessed. At baseline, anemic mothers tended (P < 0.10) to be less responsive to, and more controlling of, their infants. Infants of anemic mothers were developmentally delayed at 10 wk in hand-eye movement and overall quotient. Despite normalization of maternal iron status with supplementation in some mothers, the developmental delays were not diminished at 9 mo. At 9 mo, anemic mothers were significantly more "negative" towards their babies, engaged less in goal setting, and were less "responsive" than control mothers. In contrast, the behavior of anemic mothers given iron treatment toward their children was similar to that of the control mothers on all 11 scales of the PCIS. In conclusion, IDA altered mother-child interactions at both 10 wk and 9 mo postpartum. Additionally, infants whose mothers were anemic in the early postpartum scored worse on developmental tests at 10 wk and 9 mo of age.

Original languageEnglish (US)
Pages (from-to)850-855
Number of pages6
JournalJournal of Nutrition
Volume135
Issue number4
StatePublished - Apr 2005

Fingerprint

infant development
Mother-Child Relations
iron deficiency anemia
Iron-Deficiency Anemias
Child Development
Mothers
iron
folic acid
caregivers
infants
socioeconomic status
birth weight
placebos
Iron
hands
Postpartum Period
eyes
ascorbic acid
Folic Acid
Term Birth

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Food Science

Cite this

Perez, E. M., Hendricks, M. K., Beard, J. L., Murray-Kolb, L. E., Berg, A., Tomlinson, M., ... Vernon-Feagans, L. (2005). Mother-infant interactions and infant development are altered by maternal iron deficiency anemia. Journal of Nutrition, 135(4), 850-855.
Perez, Eva M. ; Hendricks, Michael K. ; Beard, John L. ; Murray-Kolb, Laura E. ; Berg, Astrid ; Tomlinson, Mark ; Irlam, James ; Isaacs, Washiefa ; Njengele, T. ; Sive, Alan ; Vernon-Feagans, Lynne. / Mother-infant interactions and infant development are altered by maternal iron deficiency anemia. In: Journal of Nutrition. 2005 ; Vol. 135, No. 4. pp. 850-855.
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Perez, EM, Hendricks, MK, Beard, JL, Murray-Kolb, LE, Berg, A, Tomlinson, M, Irlam, J, Isaacs, W, Njengele, T, Sive, A & Vernon-Feagans, L 2005, 'Mother-infant interactions and infant development are altered by maternal iron deficiency anemia', Journal of Nutrition, vol. 135, no. 4, pp. 850-855.

Mother-infant interactions and infant development are altered by maternal iron deficiency anemia. / Perez, Eva M.; Hendricks, Michael K.; Beard, John L.; Murray-Kolb, Laura E.; Berg, Astrid; Tomlinson, Mark; Irlam, James; Isaacs, Washiefa; Njengele, T.; Sive, Alan; Vernon-Feagans, Lynne.

In: Journal of Nutrition, Vol. 135, No. 4, 04.2005, p. 850-855.

Research output: Contribution to journalArticle

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T1 - Mother-infant interactions and infant development are altered by maternal iron deficiency anemia

AU - Perez, Eva M.

AU - Hendricks, Michael K.

AU - Beard, John L.

AU - Murray-Kolb, Laura E.

AU - Berg, Astrid

AU - Tomlinson, Mark

AU - Irlam, James

AU - Isaacs, Washiefa

AU - Njengele, T.

AU - Sive, Alan

AU - Vernon-Feagans, Lynne

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N2 - The aim of this study was to determine whether iron deficiency anemia (IDA) in young South African mothers alters mother-infant interactions and the infant's development. The study was a prospective, randomized, controlled intervention trial with 3 groups of mothers: nonanemic controls and anemic mothers administered either placebo (25 mg ascorbic acid and 10 μg folate) or daily iron treatment (125 mg FeSO4 plus ascorbate and folate). Mothers of full-term, normal birth weight infants (n = 81) were followed from 10 wk to 9 mo postpartum. Maternal iron status, socioeconomic level, mother-infant interaction [Parent/Caregiver Involvement Scale (PCIS scale)], and infant development (Griffiths scale) were assessed. At baseline, anemic mothers tended (P < 0.10) to be less responsive to, and more controlling of, their infants. Infants of anemic mothers were developmentally delayed at 10 wk in hand-eye movement and overall quotient. Despite normalization of maternal iron status with supplementation in some mothers, the developmental delays were not diminished at 9 mo. At 9 mo, anemic mothers were significantly more "negative" towards their babies, engaged less in goal setting, and were less "responsive" than control mothers. In contrast, the behavior of anemic mothers given iron treatment toward their children was similar to that of the control mothers on all 11 scales of the PCIS. In conclusion, IDA altered mother-child interactions at both 10 wk and 9 mo postpartum. Additionally, infants whose mothers were anemic in the early postpartum scored worse on developmental tests at 10 wk and 9 mo of age.

AB - The aim of this study was to determine whether iron deficiency anemia (IDA) in young South African mothers alters mother-infant interactions and the infant's development. The study was a prospective, randomized, controlled intervention trial with 3 groups of mothers: nonanemic controls and anemic mothers administered either placebo (25 mg ascorbic acid and 10 μg folate) or daily iron treatment (125 mg FeSO4 plus ascorbate and folate). Mothers of full-term, normal birth weight infants (n = 81) were followed from 10 wk to 9 mo postpartum. Maternal iron status, socioeconomic level, mother-infant interaction [Parent/Caregiver Involvement Scale (PCIS scale)], and infant development (Griffiths scale) were assessed. At baseline, anemic mothers tended (P < 0.10) to be less responsive to, and more controlling of, their infants. Infants of anemic mothers were developmentally delayed at 10 wk in hand-eye movement and overall quotient. Despite normalization of maternal iron status with supplementation in some mothers, the developmental delays were not diminished at 9 mo. At 9 mo, anemic mothers were significantly more "negative" towards their babies, engaged less in goal setting, and were less "responsive" than control mothers. In contrast, the behavior of anemic mothers given iron treatment toward their children was similar to that of the control mothers on all 11 scales of the PCIS. In conclusion, IDA altered mother-child interactions at both 10 wk and 9 mo postpartum. Additionally, infants whose mothers were anemic in the early postpartum scored worse on developmental tests at 10 wk and 9 mo of age.

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Perez EM, Hendricks MK, Beard JL, Murray-Kolb LE, Berg A, Tomlinson M et al. Mother-infant interactions and infant development are altered by maternal iron deficiency anemia. Journal of Nutrition. 2005 Apr;135(4):850-855.