Motor effects of calcitonin administered intracerebroventricularly in the rat

Michael J. Twery, Brian Kirkpatrick, Elizabeth C. Critcher, Mark H. Lewis, Richard B. Mailman, Cary W. Cooper

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

In rats treated with salmon calcitonin (CT) administered intracerebroventricularly (i.c.v., 85 or 8.5 pmol), spasmodic body movements, hopping and tail jerks, collectively termed dyskinesia, appeared within 1 h of administration and persisted for at least 24 h. In addition, spontaneous grooming, rearing and locomotion occurred less often in CT-treated rats than in vehicle-injected animals, while the incidence of both sniffing and nose poking remained essentially unchanged. The CT failed to displace either [3H]dopamine or [3H]spiperone from striatal membranes, and the behavioral effects were not blocked by haloperidol or SCH 23390, suggesting that the peptide did not directly affect dopamine receptors. The dyskinesia was not blocked by scopolamine, atropine, muscimol, diazepam or ketanserin. These data are consistent with the hypothesis that a compound with recognition characteristics similar to those of salmon CT may function as a neurotransmitter-modulator in the central nervous system.

Original languageEnglish (US)
Pages (from-to)189-198
Number of pages10
JournalEuropean Journal of Pharmacology
Volume121
Issue number2
DOIs
StatePublished - Feb 18 1986

Fingerprint

salmon calcitonin
Dyskinesias
Calcitonin
Corpus Striatum
Spiperone
Ketanserin
Grooming
Muscimol
Scopolamine Hydrobromide
Dopamine Receptors
Haloperidol
Locomotion
Diazepam
Atropine
Nose
Neurotransmitter Agents
Tail
Dopamine
Central Nervous System
Peptides

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

Twery, Michael J. ; Kirkpatrick, Brian ; Critcher, Elizabeth C. ; Lewis, Mark H. ; Mailman, Richard B. ; Cooper, Cary W. / Motor effects of calcitonin administered intracerebroventricularly in the rat. In: European Journal of Pharmacology. 1986 ; Vol. 121, No. 2. pp. 189-198.
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Motor effects of calcitonin administered intracerebroventricularly in the rat. / Twery, Michael J.; Kirkpatrick, Brian; Critcher, Elizabeth C.; Lewis, Mark H.; Mailman, Richard B.; Cooper, Cary W.

In: European Journal of Pharmacology, Vol. 121, No. 2, 18.02.1986, p. 189-198.

Research output: Contribution to journalArticle

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