Motor lateralization provides a foundation for predicting and treating non-paretic arm motor deficits in stroke

Robert L. Sainburg, Candice Maenza, Carolee Winstein, David Good

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

5 Citations (Scopus)

Abstract

Brain lateralization is a ubiquitous feature of neural organization across the vertebrate spectrum. We have developed a model of motor lateralization that attributes different motor control processes to each cerebral hemisphere. This bilateral hemispheric model of motor control has successfully predicted hemisphere-specific motor control and motor learning deficits in the ipsilesional, or non-paretic, arm of patients with unilateral stroke. We now show across large number and range of stroke patients that these motor performance deficits in the non-paretic arm of stroke patients vary with both the side of the lesion, as well as with the severity of contralesional impairment. This last point can be functionally devastating for patients with severe contralesional paresis because for these individuals, performance of upper extremity activities of daily living depends primarily and often exclusively on ipsilesional arm function. We present a pilot study focused on improving the speed and coordination of ipsilesional arm function in a convenience sample of three stroke patients with severe contralesional impairment. Over a three-week period, patients received a total of nine 1.5 h sessions of training that included intense practice of virtual reality and real-life tasks. Our results indicated substantial improvements in ipsilesional arm movement kinematics, functional performance, and that these improvements carried over to improve functional independence. In addition, the contralesional arm improved in our measure of contralesional impairment, which was likely due to improved participation in activities of daily living. We discuss of our findings for physical rehabilitation.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages257-272
Number of pages16
DOIs
StatePublished - Jan 1 2016

Publication series

NameAdvances in Experimental Medicine and Biology
Volume957
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Fingerprint

Arm
Stroke
Activities of Daily Living
Cerebrum
Paresis
Biomechanical Phenomena
Upper Extremity
Patient rehabilitation
Virtual reality
Vertebrates
Brain
Kinematics
Rehabilitation
Learning

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Sainburg, R. L., Maenza, C., Winstein, C., & Good, D. (2016). Motor lateralization provides a foundation for predicting and treating non-paretic arm motor deficits in stroke. In Advances in Experimental Medicine and Biology (pp. 257-272). (Advances in Experimental Medicine and Biology; Vol. 957). Springer New York LLC. https://doi.org/10.1007/978-3-319-47313-0_14
Sainburg, Robert L. ; Maenza, Candice ; Winstein, Carolee ; Good, David. / Motor lateralization provides a foundation for predicting and treating non-paretic arm motor deficits in stroke. Advances in Experimental Medicine and Biology. Springer New York LLC, 2016. pp. 257-272 (Advances in Experimental Medicine and Biology).
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Sainburg, RL, Maenza, C, Winstein, C & Good, D 2016, Motor lateralization provides a foundation for predicting and treating non-paretic arm motor deficits in stroke. in Advances in Experimental Medicine and Biology. Advances in Experimental Medicine and Biology, vol. 957, Springer New York LLC, pp. 257-272. https://doi.org/10.1007/978-3-319-47313-0_14

Motor lateralization provides a foundation for predicting and treating non-paretic arm motor deficits in stroke. / Sainburg, Robert L.; Maenza, Candice; Winstein, Carolee; Good, David.

Advances in Experimental Medicine and Biology. Springer New York LLC, 2016. p. 257-272 (Advances in Experimental Medicine and Biology; Vol. 957).

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

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Sainburg RL, Maenza C, Winstein C, Good D. Motor lateralization provides a foundation for predicting and treating non-paretic arm motor deficits in stroke. In Advances in Experimental Medicine and Biology. Springer New York LLC. 2016. p. 257-272. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-3-319-47313-0_14