This chapter describes mouse inbred and congenic strains. Coisogenic strains are produced when a mutation occurs at one locus in a highly inbred strain. Then the original strain and the new strain differ only at the mutated locus, because with time the pair may begin to diverge at other loci as additional mutations occur and different mutations become fixed in the two strains. Coisogenic mice can, however, also be produced by the transfer of a particular gene from one mouse into the germ cells of another mouse. But the elimination of genetic variability through the use of inbred strains is a great step toward simplification of conditions in a biological experiment, and for this reason alone, as a tool for a biochemist, inbred strains are as indispensable as pure reagents are for an analytical chemist. Sublines of congenic strains are designated similarly as sublines of inbred strains—that is, by an abbreviation of the holder placed after a slanting line. But for some strains, the subline designation in fact indicates independent derivation of a given strain in different laboratories.
All Science Journal Classification (ASJC) codes
- Molecular Biology