Mouse papillomavirus MmuPV1 infects oral mucosa and preferentially targets the base of the tongue

Nancy M. Cladel, Lynn R. Budgeon, Karla K. Balogh, Timothy Cooper, Jiafen Hu, Neil Christensen

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

In 2010, a new mouse papillomavirus, MmuPV1, was discovered in a colony of NMRI- Foxn1nu/Foxn1nu athymic mice in India. This finding was significant because it was the first papillomavirus to be found in a laboratory mouse. In this paper we report successful infections of both dorsal and ventral surfaces of the rostral tongues of outbred athymic nude mice. We also report the observation that the base of the tongue, the area of the tongue often targeted by cancer-associated high-risk papillomavirus infections in humans, is especially susceptible to infection. A suitable animal model for the study of oral papillomavirus infections, co-infections, and cancers has long been sought. The work presented here suggests that such a model is now at hand.

Original languageEnglish (US)
Pages (from-to)73-80
Number of pages8
JournalVirology
Volume488
DOIs
StatePublished - Jan 15 2016

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Mouth Mucosa
Tongue
Nude Mice
Papillomavirus Infections
Infection
Coinfection
India
Neoplasms
Animal Models
Hand

All Science Journal Classification (ASJC) codes

  • Virology

Cite this

Cladel, Nancy M. ; Budgeon, Lynn R. ; Balogh, Karla K. ; Cooper, Timothy ; Hu, Jiafen ; Christensen, Neil. / Mouse papillomavirus MmuPV1 infects oral mucosa and preferentially targets the base of the tongue. In: Virology. 2016 ; Vol. 488. pp. 73-80.
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Mouse papillomavirus MmuPV1 infects oral mucosa and preferentially targets the base of the tongue. / Cladel, Nancy M.; Budgeon, Lynn R.; Balogh, Karla K.; Cooper, Timothy; Hu, Jiafen; Christensen, Neil.

In: Virology, Vol. 488, 15.01.2016, p. 73-80.

Research output: Contribution to journalArticle

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