MRI evaluation of asymmetry of nigrostriatal damage in the early stage of early-onset Parkinson's disease

Jian-li Wang, Qing Yang, Xiaoyu Sun, Jeffrey Vesek, Zachary Mosher, Megha Vasavada, Jonathan Chu, Sangam Kanekar, Vikram Shivkumar, Kala Venkiteswaran, Thyagarajan Subramanian

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Introduction: The motor symptoms and signs of early-onset idiopathic Parkinson's disease (PD) in Hoehn and Yahr (H&Y) stage-1 are generally unilateral. We hypothesized that there would be detectable differences in the quantitative MRI parameters in these PD patients between the hemispheres contralateral to the clinically symptomatic and non-symptomatic body side. Methods: We tested this hypothesis by comparing transverse relaxation rates and diffusion tensor imaging (DTI) parameters in the substantia nigra and putamen between the two hemispheres contralateral to the symptomatic and non-symptomatic side in H&Y stage-1 PD patients who had onset of symptoms between ages of 40-59 years. Results: There were quantifiable hemispheric asymmetries in transverse relaxation rates in the substantia nigra, as well as fractional anisotropy and mean diffusivity in the putamen in early PD, which correlated with the unilaterality of motor symptoms as evaluated using the motor portion of the Unified Parkinson's Disease Rating Scale. Conclusion: Transverse relaxation mapping and DTI demonstrated significant differences between the symptomatic and non-symptomatic hemispheres at the early stage of early-onset PD. These findings support the hypothesis of asymmetric neurodegeneration in the bilateral nigrostriatal pathways in the early stage of the disease.

Original languageEnglish (US)
Pages (from-to)590-596
Number of pages7
JournalParkinsonism and Related Disorders
Volume21
Issue number6
DOIs
StatePublished - Jun 1 2015

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Parkinson Disease
Diffusion Tensor Imaging
Putamen
Substantia Nigra
Anisotropy
Signs and Symptoms

All Science Journal Classification (ASJC) codes

  • Neurology
  • Geriatrics and Gerontology
  • Clinical Neurology

Cite this

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title = "MRI evaluation of asymmetry of nigrostriatal damage in the early stage of early-onset Parkinson's disease",
abstract = "Introduction: The motor symptoms and signs of early-onset idiopathic Parkinson's disease (PD) in Hoehn and Yahr (H&Y) stage-1 are generally unilateral. We hypothesized that there would be detectable differences in the quantitative MRI parameters in these PD patients between the hemispheres contralateral to the clinically symptomatic and non-symptomatic body side. Methods: We tested this hypothesis by comparing transverse relaxation rates and diffusion tensor imaging (DTI) parameters in the substantia nigra and putamen between the two hemispheres contralateral to the symptomatic and non-symptomatic side in H&Y stage-1 PD patients who had onset of symptoms between ages of 40-59 years. Results: There were quantifiable hemispheric asymmetries in transverse relaxation rates in the substantia nigra, as well as fractional anisotropy and mean diffusivity in the putamen in early PD, which correlated with the unilaterality of motor symptoms as evaluated using the motor portion of the Unified Parkinson's Disease Rating Scale. Conclusion: Transverse relaxation mapping and DTI demonstrated significant differences between the symptomatic and non-symptomatic hemispheres at the early stage of early-onset PD. These findings support the hypothesis of asymmetric neurodegeneration in the bilateral nigrostriatal pathways in the early stage of the disease.",
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MRI evaluation of asymmetry of nigrostriatal damage in the early stage of early-onset Parkinson's disease. / Wang, Jian-li; Yang, Qing; Sun, Xiaoyu; Vesek, Jeffrey; Mosher, Zachary; Vasavada, Megha; Chu, Jonathan; Kanekar, Sangam; Shivkumar, Vikram; Venkiteswaran, Kala; Subramanian, Thyagarajan.

In: Parkinsonism and Related Disorders, Vol. 21, No. 6, 01.06.2015, p. 590-596.

Research output: Contribution to journalArticle

TY - JOUR

T1 - MRI evaluation of asymmetry of nigrostriatal damage in the early stage of early-onset Parkinson's disease

AU - Wang, Jian-li

AU - Yang, Qing

AU - Sun, Xiaoyu

AU - Vesek, Jeffrey

AU - Mosher, Zachary

AU - Vasavada, Megha

AU - Chu, Jonathan

AU - Kanekar, Sangam

AU - Shivkumar, Vikram

AU - Venkiteswaran, Kala

AU - Subramanian, Thyagarajan

PY - 2015/6/1

Y1 - 2015/6/1

N2 - Introduction: The motor symptoms and signs of early-onset idiopathic Parkinson's disease (PD) in Hoehn and Yahr (H&Y) stage-1 are generally unilateral. We hypothesized that there would be detectable differences in the quantitative MRI parameters in these PD patients between the hemispheres contralateral to the clinically symptomatic and non-symptomatic body side. Methods: We tested this hypothesis by comparing transverse relaxation rates and diffusion tensor imaging (DTI) parameters in the substantia nigra and putamen between the two hemispheres contralateral to the symptomatic and non-symptomatic side in H&Y stage-1 PD patients who had onset of symptoms between ages of 40-59 years. Results: There were quantifiable hemispheric asymmetries in transverse relaxation rates in the substantia nigra, as well as fractional anisotropy and mean diffusivity in the putamen in early PD, which correlated with the unilaterality of motor symptoms as evaluated using the motor portion of the Unified Parkinson's Disease Rating Scale. Conclusion: Transverse relaxation mapping and DTI demonstrated significant differences between the symptomatic and non-symptomatic hemispheres at the early stage of early-onset PD. These findings support the hypothesis of asymmetric neurodegeneration in the bilateral nigrostriatal pathways in the early stage of the disease.

AB - Introduction: The motor symptoms and signs of early-onset idiopathic Parkinson's disease (PD) in Hoehn and Yahr (H&Y) stage-1 are generally unilateral. We hypothesized that there would be detectable differences in the quantitative MRI parameters in these PD patients between the hemispheres contralateral to the clinically symptomatic and non-symptomatic body side. Methods: We tested this hypothesis by comparing transverse relaxation rates and diffusion tensor imaging (DTI) parameters in the substantia nigra and putamen between the two hemispheres contralateral to the symptomatic and non-symptomatic side in H&Y stage-1 PD patients who had onset of symptoms between ages of 40-59 years. Results: There were quantifiable hemispheric asymmetries in transverse relaxation rates in the substantia nigra, as well as fractional anisotropy and mean diffusivity in the putamen in early PD, which correlated with the unilaterality of motor symptoms as evaluated using the motor portion of the Unified Parkinson's Disease Rating Scale. Conclusion: Transverse relaxation mapping and DTI demonstrated significant differences between the symptomatic and non-symptomatic hemispheres at the early stage of early-onset PD. These findings support the hypothesis of asymmetric neurodegeneration in the bilateral nigrostriatal pathways in the early stage of the disease.

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