Mucosally-derived HPV-40 can infect both human genital foreskin and cutaneous hand skin tissues grafted into athymic mice

Audrey J. Jenkins, C. Max Lang, Lynn R. Budgeon, Nancy M. Cladel, Cynthia A. Reed, Danny R. Welch, Neil D. Christensen

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

HPV-40 is a rare HPV type that has been detected only in genital mucosal tissues. This HPV type is very closely related to HPV-7, which has a predominantly cutaneous tissue tropism. We have shown, previously, that an isolate of HPV-40 (described here as HPV-40Hershey or HPV-40H) productively infected genital tissues. In this study, HPV-40H was tested for productive infection of cutaneous tissue. Fetal hand skin fragments were incubated with infectious HPV-40H and implanted subrenally into athymic mice. After 120 days, xenografts showed morphological changes consistent with HPV-40H infection and were HPV-40 DNA in situ positive and capsid antigen positive. The results demonstrated that hand skin can support HPV-40H infection thereby indicating that this viral type has the capacity to infect both genital mucosal and cutaneous tissues.

Original languageEnglish (US)
Pages (from-to)109-114
Number of pages6
JournalVirus Research
Volume93
Issue number1
DOIs
StatePublished - May 1 2003

All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Virology
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Mucosally-derived HPV-40 can infect both human genital foreskin and cutaneous hand skin tissues grafted into athymic mice'. Together they form a unique fingerprint.

  • Cite this